This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Minimally invasive versus open esophageal resection: three-year follow-up of the previously reported randomized controlled trial: The TIME Trial. Ann Surg 2017; 266: 232-236.

Published: 6th October 2017

Authors: Straatman J, van der Wielen N, Cuesta MA, Daams F, Roig Garcia J, Bonavina L et al.

Conclusion

There was no difference in three-year overall survival: 40.4% after open surgery versus 50.5% after minimally invasive surgery (P= 0.207) in this study that included 115 patients.

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Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma. The NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.

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Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer. A randomized clinical trial. JAMA Surg 2021; 156: 601-610.

Authors: Van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F et al.

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Five-year survival outcomes of hybrid minimally invasive esophagectomy in esophageal cancer. Results of the MIRO Randomized Clinical Trial. JAMA Surg 2021; 156: 323-332.

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Randomized comparison of gastric tube reconstruction with and without duodenal diversion plus Roux-en-Y anastomosis after esophagectomy. Ann Surg 2020; 272: 48-54.

Authors: Yano M, Sugimura K, Miyata H, Motoori M, Tanaka K, Omori T et al.

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Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer. Analysis of a multicenter, open-label, randomized phase III controlled trial. The MIRO Trial. Ann Surg 2020; 271: 1023-1029.

Authors: Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.

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Direct oral feeding following minimally invasive esophagectomy (NUTRIENT II trial). An international, multicenter, open-label randomized controlled trial. Ann Surg 2020; 271: 41-47

Authors: Berkelmans GH, Fransen LFC, Dolmans-Zwartjes ACP, Kouwenhoven EA, van Det MJ, Nilsson M et al.

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Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg 20129; 270: 983-991

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Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally advanced gastric cancer. The SEIPLUS randomized clinical trial. JAMA Surg 2019; 154: 610-616

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Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer. A randomized controlled trial. Ann Surg 2019; 269: 621-630.

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Hybrid minimally invasive esophagectomy for esophageal cancer. N Engl J Med 2019; 380: 152-162.

Authors: Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.

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Early oral feeding following McKeown minimally invasive esophagectomy: an open-label, randomized, controlled, noninferiority trial. Ann Surg 2018; 267: 435-442.

Authors: Sun H-B, Li Y, Liu X-B, Zhang R-X, Wang Z-F, Lerut T et al.