This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Autologous or homologous transfusion in aortic surgery: randomized trial. BJS 2001; 88: 604-604.
Published: 6th December 2002
Authors: F. Torella, J. C. L. Wong, S. L. Haynes, C. N. McCollum
Background
Aortic surgery often requires blood transfusion, which may cause complications and postoperative infection. Autologous transfusion was evaluated in a multicentre clinical trial.
Method
Some 145 patients undergoing elective aortic surgery in eight hospitals were randomized to either ‘homologous’ or ‘autologous’ transfusion, a combination of acute normovolaemic haemodilution (ANH) and intraoperative cell salvage. Homologous blood was administered when the haemoglobin concentration fell below 8 g dl−1.
Results
Median (interquartile range (i.q.r.)) blood loss was 668 (400–862) ml or 17 (10–24) per cent of blood volume in aortobifemoral bypass, and 1120 (765–1700) ml or 24 (17–36) per cent in aneurysm repair (P < 0·001). Autologous transfusion reduced homologous blood requirements from a median (i.q.r.) of 2 (0–4) units to 0 (0–2) units (P = 0·008). Independent predictors of blood transfusion were homologous transfusion strategy (odds ratio (OR) 2·3 (95 per cent confidence interval 1·1–5·0); P = 0·03), low preoperative haemoglobin concentration (OR 3·7 (1·7–8·2); P < 0·001), prolonged surgery (OR 2·1 (1·0–4·8); P = 0·05) and blood loss (OR 3·0 (1·4–6·5); P = 0·007). Patients with a preoperative haemoglobin concentration greater than 13·5 g dl−1 and who lost less than 20 per cent of their blood volume rarely required transfusion. There was no significant difference between the groups in terms of morbidity, mortality and postoperative hospital stay.
Conclusion
Autologous transfusion reduced the need for homologous blood in aortic surgery, but was useful only in patients with low haemoglobin levels or when blood loss exceeded 20 per cent of the blood volume. ANH alone is indicated for patients undergoing aortobifemoral bypass and in those with a higher haemoglobin level and blood volume. © 2001 British Journal of Surgery Society Ltd
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