This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Breast cancer recurrence after reoperation for surgical bleeding. BJS 2017; 104: 1665-1674.
Published: 7th August 2017
Authors: R. N. Pedersen, K. Bhaskaran, U. Heide‐Jørgensen, M. Nørgaard, P. M. Christiansen, N. Kroman et al.
Background
Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.
Method
Using the Danish Breast Cancer Group database and the Danish National Patient Register (
Results
Among 30 711 patients (205 926 person‐years of follow‐up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow‐up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person‐years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person‐years for non‐reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.
Conclusion
In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.
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