The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Local recurrence after surgery for primary extra‐abdominal desmoid‐type fibromatosis. BJS 2013; 100: 1214-1219.

Published: 27th June 2013

Authors: D. L. M. van Broekhoven, C. Verhoef, S. G. Elias, A. J. Witkamp, J. M. H. H. van Gorp, B. A. N. van Geel et al.

Background

Desmoid‐type fibromatosis is a locally aggressive soft tissue tumour with a biological behaviour that varies between relatively indolent and progressive growth. Although there is a trend towards conservative treatment, surgery remains the standard treatment for extra‐abdominal desmoid tumours.

Method

Databases of three hospitals were searched to identify patients who had been treated for desmoid‐type fibromatosis between November 1989 and May 2011. The risk of local recurrence was evaluated and predictive factors were assessed in patients who underwent surgical resection as initial treatment for a primary tumour.

Results

A total of 132 patients had surgical treatment for a primary tumour. A complete resection (R0) was achieved in 87 patients (65·9 per cent). In addition to surgery, 54 patients received radiotherapy. During a median follow‐up of 38 months, 18 local recurrences were detected. The estimated 5‐year cumulative risk of local recurrence was 17·6 per cent. Univariable Cox regression analysis demonstrated that the risk of local recurrence increased for extremity lesions compared with desmoids on the trunk (odds ratio 6·69, 95 per cent confidence interval 1·42 to 31·54). No significant influence of age, resection margins or adjuvant radiotherapy on the risk for local recurrence was observed.

Conclusion

Following surgical treatment of a primary extra‐abdominal desmoid tumour, the 5‐year risk of local recurrence is modest and not influenced by microscopically clear resection margins or adjuvant radiotherapy.

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