This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Meta‐analysis of the prognostic value of CpG island methylator phenotype in gastric cancer. BJS 2018; 105: e61-e68.
Published: 17th January 2018
Authors: A. G. M. T. Powell, S. Soul, A. Christian, W. G. Lewis
Background
CpG island methylator phenotype (CIMP) has been identified as a distinct molecular subtype of gastric cancer, yet associations with survival are conflicting. A meta‐analysis was performed to estimate the prognostic significance of CIMP.
Method
Embase, MEDLINE, PubMed, PubMed Central and Cochrane databases were searched systematically for studies related to the association between CIMP and survival in patients undergoing potentially curative resection for gastric cancer.
Results
A total of 918 patients from ten studies were included, and the median proportion of tumours with CIMP‐high (CIMP‐H) status was 40·9 (range 4·8–63) per cent. Gene panels for assessing CIMP status varied between the studies. Pooled analysis suggested that specimens exhibiting CIMP‐H were associated with poorer 5‐year survival (odds ratio (OR) for death 1·48, 95 per cent c.i. 1·10 to 1·99;
Conclusion
There was heterogeneity in the gene panels used to identify CIMP, which may explain the survival differences.
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