This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Platelet function and antiplatelet therapy. BJS 2007; 94: 674-682.
Published: 18th May 2007
Authors: M. Troxler, K. Dickinson, S. Homer‐Vanniasinkam
Background
Platelets have roles other than haemostasis and many are relevant to surgical practice. This review examines both the pathophysiology of platelets in haemostasis and thrombosis, and other roles of clinical importance.
Method
A literature review of the various functional roles of platelets was performed (Medline search, English language) including their action in inflammation (in particular in atherothrombosis), antimicrobial defence and tumour growth. Current clinical evidence for antiplatelet therapy is also reviewed.