Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Meta-analysis of randomized clinical trials of adjuvant chemotherapy for resected biliary tract cancers. HPB (Oxford). 2020 Jul;22(7):939-949

Authors: Ma WJ, Jin YW, Wu ZR, Yang Q, Wang JK, Liu F et al.

Scientific Surgery

Adjuvant chemotherapy in resected bile duct cancer: A systematic review and meta-analysis of randomized trials. Crit Rev Oncol Hematol 2019; 143: 124-129

Authors: Messina C , Merz V , Frisinghelli M , Trentin C , Grego E , Veccia A et al.

Scientific Surgery

A prospective, randomized phase II study of adjuvant gemcitabine versus S-1 after major hepatectomy for biliary tract cancer (KHBO 1208). Ann Surg 2019; 270: 230-237.

Authors: Kobayashi S, Nagano H, Tomokuni A, Gotoh K, Sakai D, Hatano E et al.

Scientific Surgery

Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel arm, non-inferiority trial. Lancet 2019; 393: 2322-2330.

Authors: Van Dijk AH, Wennmacker SZ, de Reuver PR, Latenstein CS, Buyne O, Donkervoort SC et al.

Scientific Surgery

Quality of life after single-incision laparoscopic cholecystectomy: A randomized, clinical trial. Surgery 2019; 165: 353-359.

Authors: Ito I, Takai A, Imai Y, Otani H, Onishi Y, Yamamoto Y et al.

Scientific Surgery

Effects of preoperative oral carbohydrates on quality of recovery in laparoscopic cholecystectomy: a randomized, double blind, placebo-controlled trial. World J Surg 2018; 42: 3150–3157.

Authors: Lee JS, Song Y, Kim JY, Park JS, Yoon DS

Scientific Surgery

Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial. BMJ 2018; 363: k3965.

Authors: Loozen CS, van Santvoort HC, van Duijvendijk P, Besselink MG, Gouma DJ, Nieuwenhuijzen GA et al.

Scientific Surgery

Extended antibiotic therapy versus placebo after laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis: A randomized double-blind clinical trial. Surgery 2018; 164: 24-30.

Authors: de Santibañes M, Glinka J, Pelegrini P, Alvarez FA, Elizondo C, Giunta D et al.

Scientific Surgery

Are postoperative intravenous fluids in patients undergoing elective laparoscopic cholecystectomy a necessity? A randomized clinical trial. Surgery 2018; 163: 721-725.

Authors: Henriques JR, Correia MI

Scientific Surgery

Percutaneous transhepatic gallbladder drainage combined with laparoscopic cholecystectomy: a meta-analysis of randomized controlled trials. J Lap Endosc Adv Surg Tech A 2018; 28: 248-255.

Authors: Tan H-Y, Jiang D-D, Li J, He K, Yang K

Scientific Surgery

Single-incision versus 3-port laparoscopic cholecystectomy in symptomatic gallstones: A prospective randomized study. Surgery 2017; 162: 96-103.

Authors: Omar MA, Redwan AA, Mahmoud AG

Scientific Surgery

Interest of using ropivacaine for outpatient laparoscopic cholecystectomy: prospective randomized trial. World J Surg 2017; 41: 687–692.

Authors: Abet E, Orion F, Denimal F, Brau-Weber A-G, De Kerviler B, Jean M-H et al.

Scientific Surgery

Antireflux versus conventional plastic stent in malignant biliary obstruction: a prospective randomized study. J Laparoendosc Adv Surg Tech 2017; 27: 53-57.

Authors: Vihervaara H, Grönroos JM, Hurme S, Gullichsen R, Salminen P

Scientific Surgery

Early versus delayed cholecystectomy for acute cholecystitis, are the 72 hours still the rule?: a randomized trial. Ann Surg 2016; 264: 717-722.

Authors: Roulin D, Saadi A, Di Mare L, Demartines N, Halkic N

Scientific Surgery

Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial. Lancet 2016; 387: 2293–2301.

Authors: Luo H, Zhao L, Leung J, Zhang R, Liu Z, Wang X et al.

Scientific Surgery

Single-incision laparoscopic cholecystectomy versus traditional laparoscopic cholecystectomy performed by a single surgeon: findings of a randomized trial. Surg Today 2016; 46: 313-318.

Authors: Partelli S, Barugola G, Sartori A, Crippa S, Falconi M, Ruffo G et al.

Scientific Surgery

Pilot randomized controlled trial of laparoscopic cholecystectomy vs active nonoperative therapy for the treatment of biliary dyskinesia. J Am Coll Surg 2016; 222: 1156–1163.

Authors: Richmond BK, Grodman C, Walker J, Dean S, Tiley EH, Hamrick RE et al.

Scientific Surgery

Management and outcome of borderline common bile duct with stones: a prospective randomized study. J Lap Adv Surg Tech A 2016; 26: 161-167.

Authors: El Nakeeb A, El Geidie A, El Hanafy E, Atef E, Askar W, Sultan AM et al.

Scientific Surgery

Effect of covered metallic stents compared with plastic stents on benign biliary stricture resolution: a randomized clinical trial. JAMA. 2016; 315: 1250-1257.

Authors: Coté GA, Slivka A, Tarnasky P, Mullady DK, Elmunzer J, Elta G et al.

Scientific Surgery

Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: A randomized phase 2 trial (Vecti-BIL study). Cancer 2016; 122: 574-581.

Authors: Leone F, Marino D, Cereda S, Filippi R, Belli C, Spadi R et al.

Scientific Surgery

Efficacy of a laparoscopically delivered transversus abdominis plane block technique during elective laparoscopic cholecystectomy: a prospective, double-blind randomized trial. J Am Coll Surg 2015; 221: 335–344.

Authors: Elamin G, Waters PS, Hamid H, O’Keefe HM, Waldron RM, Duggan M et al. et al.

Scientific Surgery

Effects of intra-abdominally instilled isotonic saline on pain, recovery, and health-related quality-of-life following laparoscopic cholecystectomy: a randomized prospective double-blind controlled study. World J Surg 2015; 39: 1413-1420.

Authors: Barthelsson C, Sandblom G, Ljesevic-Nikoletic S, Hammarqvist F

Scientific Surgery

Cosmesis and body image in patients undergoing single-port versus conventional laparoscopic cholecystectomy: a multicenter double-blinded randomized controlled trial (SPOCC-trial). Ann Surg 2015; 262: 728–735.

Authors: Lurje G, Raptis DA, Steinemann DC, Amygdalos I, Kambakamba P, Petrowsky H et al. et al.

Scientific Surgery

A double-blinded randomized trial to compare the effectiveness of minimally invasive procedures using patient-reported outcomes. J Am Coll Surg 2015; 221: 111–121.

Authors: Bingener J, Skaran P, McConico A, Novotny P, Wettstein P, Sletten DM et al. et al.

Scientific Surgery

Low-pressure versus standard-pressure pneumoperitoneum for laparoscopic cholecystectomy: a systematic review and meta-analysis. Am J Surg 2014; 208: 143-150.

Authors: Hua J, Gong J, Yao L, Zhou B, Song Z

Scientific Surgery

Initial cholecystectomy vs. sequential common duct endoscopic assessment and subsequent cholecystectomy for suspected gallstone migration. A randomized clinical trial. JAMA 2014; 312: 137-144.

Authors: Iranmanesh P, Frossard J-L, Mugnier-Konrad B, Morel P, Majno P, Nguyen-Tang T et al. et al.

Scientific Surgery

Laparoscopic versus endoscopic management of choledocholithiasis in patients undergoing laparoscopic cholecystectomy: a meta-analysis. J Laparoendosc Adv Surg Tech A 2014; 24: 287-294.

Authors: Liu JG, Wang YJ, Shu GM, Lou C, Zhang J, Du Z et al.

Scientific Surgery

Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute acalculous cholecystitis. A randomized clinical trial. JAMA 2014; 312: 145-154.

Authors: Regimbeau JM, Fuks D, Pautrat K, Mauvais F, Haccart V, Msika S et al. et al.

Scientific Surgery

Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy. The EPISOD randomized clinical trial. JAMA 2014; 311: 2101-2109.

Authors: Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnaskey P et al. et al.

Scientific Surgery

Comparison of laparoscopic bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis: a prospective randomized trial. Am J Surg 2013; 206: 457-463.

Authors: Koc B, Karahan S, Adas G, Tutal F, Guven H, Ozscy A et al.

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