Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Hypothermic oxygenated machine perfusion reduces early allograft injury and improves post-transplant outcomes in extended criteria donation liver transplantation from donation after brain death. Ann Surg 2021; 274: 705-712.

Authors: Czigany Z, Pratschke J, Froněk J, Guba M, Schöning W, Raptis DA et al.

Scientific Surgery

Open preperitoneal inguinal hernia repair, TREPP versus TIPP in a randomized clinical trial. Ann Surg 2021; 274: 698-704.

Authors: Bökkerink W, Koning G, Vriens PW, Mollen R, Harker M, Noordhof RK et al.

Scientific Surgery

Incisional surgical site infections after mass and layered closure of upper abdominal transverse incisions. First results of a randomized controlled trial. Ann Surg 2021; 274: 690-697.

Authors: Grąt M, Morawski M, Krasnodębski M, Borkowski J, Krawczyk P, Grąt K et al.

Scientific Surgery

Central venous access devices for the delivery of systemic anticancer therapy (CAVA): a randomised controlled trial. Lancet 2021; 398: 403-415.

Authors: Moss JG, Wo O, Bodenham AR, Agarwal R, Menne TF, Jones BL et al.

Scientific Surgery

Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation. A multicenter randomized clinical trial. Ann Surg 2021; 274: e370-e380.

Authors: Blakely M, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK et al.

Scientific Surgery

Randomized controlled study investigating the effect of a dedicated in-house art gallery on the recovery of patients after major oncologic surgery. Ann Surg 2021; 274: 264-270.

Authors: Lone Z, Hussein AA, Khan H, Steele M, Jing Z, Attwood K et al.

Scientific Surgery

Meta-analysis and systematic review of the use of a prosthetic mesh for prevention of parastomal hernia. Ann Surg 2021; 274: 20-28.

Authors: Prudhomme M, Fabbro-Peray P, Rullier E, Occean BV, Bertrand MM

Scientific Surgery

Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant. A randomized clinical trial. JAMA Surg 2021; 156: 517-525.

Authors: Husen P, Boffa C, Jochmans I, Krikke C, Davies L, Mazilescu L et al.

Scientific Surgery

Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

Authors: Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger TS, Kranke P et al.

Scientific Surgery

Effect of a predictive model on planned surgical duration accuracy, patient wait time, and use of presurgical resources. A randomized clinical trial. JAMA Surg 2021; 156 :315-321.

Authors: Strömblad CT, Baxter-King R, Meisami A, Yee S-J, Levine MR, Ostrovsky A et al.

Scientific Surgery

Early corticosteroid cessation vs long-term corticosteroid therapy in kidney transplant recipients. Long-term outcomes of a randomized clinical trial. JAMA Surg 2021; 156: 307-314.

Authors: Woodle ES, Gill JS, Clark S, Stewart D, Alloway R, First R et al.

Scientific Surgery

Robotic versus laparoscopic ventral hernia repair. One-year results from a prospective, multicenter, blinded randomized controlled trial. Ann Surg 2021; 273: 1076-1080.

Authors: Dhanani N, Olavarria O, Holihan J, Shah S, Wilson T, Loor M et al.

Scientific Surgery

Effect of cognitive prehabilitation on the incidence of postoperative delirium among older adults undergoing major noncardiac surgery. The Neurobics randomized clinical trial. JAMA Surg 2021; 156: 148-156.

Authors: Humeidan ML, Reyes J-PC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan C et al.

Scientific Surgery

Impact of mesh and fixation on chronic inguinal pain in Lichtenstein hernia repair: 5-year outcomes from the Finn Mesh Study. World J Surgery 2021; 45: 459–464.

Authors: Matikainan M, Vironen J, Kossi J, Hulmi T, Hertsi M, Rantanen T et al.

Scientific Surgery

Prophylactic single-use negative pressure dressing in closed surgical wounds after incisional hernia repair. A randomized, controlled trial. Ann Surg 2021; 273: 1081-1086.

Authors: Bueno-Lledó J, Franco-Bernal A, Garcia-Voz-Mediano MT, Torregrosa-Gallud A, Bonafé S

Scientific Surgery

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021; 397: 2253-2263.

Authors: Lopes RD, de barros e Silva PGM, Furtado RHM, Macedo AVS, Bronhara B, Damiani LP et al.

Scientific Surgery

Dexamethasone and surgical-site infection. N Engl J Med 2021; 384: 1731-1741.

Authors: Corcoran TB, Myles PS, Forbes AB, Cheng AC, Bach LA, O’Loughlin E et al.

Scientific Surgery

Heavyweight mesh is superior to lightweight mesh in laparo-endoscopic inguinal hernia repair. A meta-analysis and trial sequential analysis of randomized controlled trials. Ann Surg 2021; 273: 890-899.

Authors: Bakker W, Aufenacker TJ, Boschman JS, Burgmans JP

Scientific Surgery

Hypothermic machine perfusion in liver transplantation — a randomized trial. N Engl J Med 2021; 384: 1391-1401.

Authors: Van Rijn R, Schurink II, de Vries Y, van den Berg AP, Cerisuelo MC, Murad AD et al.

Scientific Surgery

Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury. A double-blind, placebo-controlled, randomized clinical trial. JAMA Surg 2020; 156: 11-20.

Authors: Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ et al.

Scientific Surgery

Prophylactic topical tranexamic acid versus placebo in surgical patients. A systematic review and meta-analysis. Ann Surg 2021; 273: 676-683.

Authors: Teoh WY, Tan TG, Ng KT, Ong KX, Chan XL, Hung T et al.

Scientific Surgery

Preventing recurrence in clean and contaminated hernias using biologic versus synthetic mesh in ventral hernia repair. The PRICE randomized clinical trial. Ann Surg 2021; 273: 648-655.

Authors: Harris H, Primus F, Young C, Carter JT, Lin M, Mukhtar R et al.

Scientific Surgery

Patient-reported outcomes of robotic vs laparoscopic ventral hernia repair with intraperitoneal mesh. The PROVE-IT randomized clinical trial. JAMA Surg 2021; 156: 22-29.

Authors: Petro CC, Zolin S, Krpata D, Alkhatib H, Tu C, Rosen MJ et al.

Scientific Surgery

Simple wound Irrigation in the postoperative treatment for surgically drained spontaneous soft tissue abscesses: a prospective, randomized controlled trial. World J Surg 2020; 44: 4041-4051.

Authors: Oehme F, Ruhle A, Bornert K, Hempel S, Link B-C, Babst R et al.

Scientific Surgery

Effect of prophylactic embolization on patients with blunt trauma at high risk of splenectomy. A Randomized Clinical Trial. JAMA Surg 2020; 155: 1102-1111.

Authors: Arvieux C, Frandon J, Tidadini F, Monnin-Bares V, Foote A, Dubuisson V et al.

Scientific Surgery

Negative pressure wound therapy vs conventional wound treatment in subcutaneous abdominal wound healing impairment. The SAWHI randomized clinical trial. JAMA Surg 2020; 155: 469-478.

Authors: Seidel D, Diedrich S, Herrle F, Thielemann H, Marusch F, Schirren R et al.

Scientific Surgery

Synthetic versus biological mesh in laparoscopic and open ventral hernia repair (LAPSIS). Results of a multinational, randomized, controlled, and double-blind trial. Ann Surg 2021; 273: 57-65.

Authors: Miserez M, Lefering R, Famiglietti F, Mathes T, Seidel D, Sauerland S et al.

Scientific Surgery

Robotic inguinal vs transabdominal laparoscopic inguinal hernia repair. The RIVAL randomized clinical trial. JAMA Surg 2020; 155: 380-387.

Authors: Prabhu A, Carbonell A, Hope W, Warren J, Higgins R, Jacob B et al.

Scientific Surgery

A single preoperative dose of tranexamic acid reduces perioperative blood loss. A meta-analysis. Ann Surg 2021; 273: 75-81.

Authors: Heyns M, Knight P, Steve AK, Yeung JK

Scientific Surgery

Primary open versus closed implantation strategy for totally implantable venous access ports. The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900). Ann Surg 2020; 272: 950-960.

Authors: Hüttner F, Bruckner T, Hackbusch M, Weitz J, Bork U, Kotschenreuther P et al.

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