Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis. Lancet Gastro Hepatol 2021; 9: 733-742.

Authors: Akshintala VS, Weiland CJS, Bhullar FA, Kamal A, Kanthasamy K, Kuo A et al.

Scientific Surgery

Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.

Authors: Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL et al.

Scientific Surgery

Immediate oral refeeding in patients with mild and moderate acute pancreatitis. A multicenter, randomized controlled trial (PADI trial). Ann Surg 2021; 274: 255-263.

Authors: Ramírez-Maldonado E, Gordo SL, Pueyo EM, Sánchez-García A, Mayol S, González S et al.

Scientific Surgery

Safety of combined division vs separate division of the splenic vein in patients undergoing distal pancreatectomy. A noninferiority randomized clinical trial. JAMA Surg 2021; 156: 418-428.

Authors: Yamada S, Fujii T, Sonohara F, Kawai M, Shibuya K, Matsumoto I et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Anterior approach vs conventional hepatectomy for resection of colorectal liver metastasis. A randomized clinical trial. JAMA Surg 2021; 156: 31-40.

Authors: Rahbari NN, Birgin E, Bork U, Mehrabi A, Reißfelder C, Weitz J et al.

Scientific Surgery

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. Gut 2020; 69: 1492-1501.

Authors: Kudo M, Ueshima K, Ikeda M, Torimura T, Tanebe N, Aikata H et al.

Scientific Surgery

Drain placement after uncomplicated hepatic resection increases severe postoperative complication rate. A Japanese multi-institutional randomized controlled trial (ND-trial). Ann Surg 2021; 273: 224-231.

Authors: Arita J, Sakamaki K, Saiura A, Konishi M, Sakamoto Y, Hashimoto M et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.

Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.

Scientific Surgery

Simultaneous versus delayed resection for initially resectable synchronous colorectal cancer liver metastases. A prospective, open-label, randomized, controlled trial. Ann Surg 2021; 273: 49-56.

Authors: Boudjema K, Locher C, Sabbagh C, Ortega-Deballon P, Heyd B, Bachellier P et al.

Scientific Surgery

A systematic review and network-meta-analysis of gastro-enteric reconstruction techniques following pancreatoduodenectomy to reduce delayed gastric emptying. World J Surg 2020; 44: 2314-2322.

Authors: Kamarajah SK, Bundred JR, Alessandri G, Robinson SM, Wilson CH, French JJ et al.

Scientific Surgery

Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis. A single-center, phase 3, randomized clinical trial. JAMA Surg 2020; 155: 313-321.

Authors: Andrianello S, Marchegiani G, Malleo G, Masini G, Balduzzi A, Paiella S et al.

Scientific Surgery

Adjuvant 131I-metuximab for hepatocellular carcinoma after liver resection: a randomised, controlled, multicentre, open-label, phase 2 trial. Lancet Gastroenterol Hepatol 2020; 5: 548-560.

Authors: Li J, Xing J, Yang Y, Liu J, Wang W, Xia Y et al.

Scientific Surgery

Effect of hydrocortisone vs pasireotide on pancreatic surgery complications in patients with high risk of pancreatic fistula. A randomized clinical trial. JAMA Surg 2020; 155: 291-298.

Authors: Tarvainen T, Siren J, Kokkola A, Sallinen V

Scientific Surgery

Intention to control low central venous pressure reduced blood loss during laparoscopic hepatectomy: A double-blind randomized clinical trial. Surgery 2020; 167: 933-941.

Authors: Pan Y-X, Wang J-C, Lu X-Y , Chen J-B, He W, Chen J-C et al.

Scientific Surgery

Survival advantage of laparoscopic versus open resection for colorectal liver metastases. A meta-analysis of individual patient data from randomized trials and propensity-score matched studies. Ann Surg 2020; 272: 253-265.

Authors: Syn NL, Kabir T, Koh YY, Tan HL, Wang LZ, Chin BZ et al.

Scientific Surgery

Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020; 396: 167-176.

Authors: Schepers NJ, Hallensleben NDL, Besselink MG, Anten M-PG, Bollen TL, da Costa DW et al.

Scientific Surgery

Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomized controlled trials. J Clin Med. 2020; 9: 1129.

Authors: Cloyd JM, Heh V, Pawlik TM, Ejaz A, Dillhoff M, Tsung A et al.

Scientific Surgery

Meta-analysis of randomized clinical trials of adjuvant chemotherapy for resected biliary tract cancers. HPB (Oxford). 2020 Jul;22(7):939-949

Authors: Ma WJ, Jin YW, Wu ZR, Yang Q, Wang JK, Liu F et al.

Scientific Surgery

Antimicrobial prophylaxis for 1 day versus 3 days in liver cancer surgery: a randomized controlled non-inferiority trial. Surg Today 2019; 49: 859-869

Authors: Takayama T, Aramaki O, Shibata T, Oka M, Itamoto T, Shimada M et al.

Scientific Surgery

Effect of remote ischemic preconditioning conducted in living liver donors on postoperative liver function in donors and recipients following liver transplantation. A randomized clinical trial. Ann Surg 2000; 271: 646-653

Authors: Jung K-W, Kang J, Kwon H-M, Moon Y-J, Jun I-G, Song J-G et al.

Scientific Surgery

The effect of fibrinogen/thrombin-coated collagen patch (TachoSil) application in pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: a randomized clinical trial. World J Surg 2019; 43: 3128–3137

Authors: Kwon J, Shin SH, Lee S, Park G, Park Y, Lee SJ et al.

Scientific Surgery

Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247

Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.

Scientific Surgery

Antibiotic irrigation during pancreatoduodenectomy to prevent infection and pancreatic fistula: a randomized controlled clinical trial. Surgery 2019; 166: 469-475

Authors: Maatman TK, Weber DJ, Timsina LR, Zyromski NJ, Koniaris LG, House MG et al.

Scientific Surgery

Laparoscopic versus open pancreaticoduodenectomy. A systematic review and meta-analysis of randomized controlled trials. Ann Surg 2020; 271: 54-66

Authors: Nickel F, Haney CM, Kowalewski KF, Probst P, Limen EF, Kalkum E et al.

Scientific Surgery

Does the artery-first approach improve the rate of R0 resection in pancreatoduodenectomy? A multicenter, randomized, controlled trial. Ann Surg 2019; 270: 738-746

Authors: Sabater L, Cugat E, Serrablo A, Suarez-Artacho G, Diez-Valladares L, Santoyo-Santoyo J et al.

Scientific Surgery

Adjuvant chemotherapy in resected bile duct cancer: A systematic review and meta-analysis of randomized trials. Crit Rev Oncol Hematol 2019; 143: 124-129

Authors: Messina C , Merz V , Frisinghelli M , Trentin C , Grego E , Veccia A et al.

Scientific Surgery

Gallstone pancreatitis: admission versus normal cholecystectomy—a randomized trial (Gallstone PANC Trial). Ann Surg 2019; 270: 519-527

Authors: Mueck K, Wei S , Pedroza C , Bernardi K , Jackson ML , Liang MK et al.

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