Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Anterior approach vs conventional hepatectomy for resection of colorectal liver metastasis. A randomized clinical trial. JAMA Surg 2021; 156: 31-40.

Authors: Rahbari NN, Birgin E, Bork U, Mehrabi A, Reißfelder C, Weitz J et al.

Scientific Surgery

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. Gut 2020; 69: 1492-1501.

Authors: Kudo M, Ueshima K, Ikeda M, Torimura T, Tanebe N, Aikata H et al.

Scientific Surgery

Drain placement after uncomplicated hepatic resection increases severe postoperative complication rate. A Japanese multi-institutional randomized controlled trial (ND-trial). Ann Surg 2021; 273: 224-231.

Authors: Arita J, Sakamaki K, Saiura A, Konishi M, Sakamoto Y, Hashimoto M et al.

Scientific Surgery

Simultaneous versus delayed resection for initially resectable synchronous colorectal cancer liver metastases. A prospective, open-label, randomized, controlled trial. Ann Surg 2021; 273: 49-56.

Authors: Boudjema K, Locher C, Sabbagh C, Ortega-Deballon P, Heyd B, Bachellier P et al.

Scientific Surgery

Adjuvant 131I-metuximab for hepatocellular carcinoma after liver resection: a randomised, controlled, multicentre, open-label, phase 2 trial. Lancet Gastroenterol Hepatol 2020; 5: 548-560.

Authors: Li J, Xing J, Yang Y, Liu J, Wang W, Xia Y et al.

Scientific Surgery

Intention to control low central venous pressure reduced blood loss during laparoscopic hepatectomy: A double-blind randomized clinical trial. Surgery 2020; 167: 933-941.

Authors: Pan Y-X, Wang J-C, Lu X-Y , Chen J-B, He W, Chen J-C et al.

Scientific Surgery

Survival advantage of laparoscopic versus open resection for colorectal liver metastases. A meta-analysis of individual patient data from randomized trials and propensity-score matched studies. Ann Surg 2020; 272: 253-265.

Authors: Syn NL, Kabir T, Koh YY, Tan HL, Wang LZ, Chin BZ et al.

Scientific Surgery

Antimicrobial prophylaxis for 1 day versus 3 days in liver cancer surgery: a randomized controlled non-inferiority trial. Surg Today 2019; 49: 859-869

Authors: Takayama T, Aramaki O, Shibata T, Oka M, Itamoto T, Shimada M et al.

Scientific Surgery

Effect of remote ischemic preconditioning conducted in living liver donors on postoperative liver function in donors and recipients following liver transplantation. A randomized clinical trial. Ann Surg 2000; 271: 646-653

Authors: Jung K-W, Kang J, Kwon H-M, Moon Y-J, Jun I-G, Song J-G et al.

Scientific Surgery

The effect of fibrinogen/thrombin-coated collagen patch (TachoSil) application in pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: a randomized clinical trial. World J Surg 2019; 43: 3128–3137

Authors: Kwon J, Shin SH, Lee S, Park G, Park Y, Lee SJ et al.

Scientific Surgery

Antibiotic irrigation during pancreatoduodenectomy to prevent infection and pancreatic fistula: a randomized controlled clinical trial. Surgery 2019; 166: 469-475

Authors: Maatman TK, Weber DJ, Timsina LR, Zyromski NJ, Koniaris LG, House MG et al.

Scientific Surgery

Laparoscopic versus open pancreaticoduodenectomy. A systematic review and meta-analysis of randomized controlled trials. Ann Surg 2020; 271: 54-66

Authors: Nickel F, Haney CM, Kowalewski KF, Probst P, Limen EF, Kalkum E et al.

Scientific Surgery

Does the artery-first approach improve the rate of R0 resection in pancreatoduodenectomy? A multicenter, randomized, controlled trial. Ann Surg 2019; 270: 738-746

Authors: Sabater L, Cugat E, Serrablo A, Suarez-Artacho G, Diez-Valladares L, Santoyo-Santoyo J et al.

Scientific Surgery

A randomized controlled trial comparing epidural analgesia versus continuous local anesthetic infiltration via abdominal wound catheter in open liver resection. Ann Surg 2019; 269: 413-419.

Authors: Bell R, Ward D, Jeffery J, Toogood G, Lodge JP, Rao K et al.

Scientific Surgery

Short-term preoperative diet decreases bleeding after partial hepatectomy. Results from a multi-institutional randomized controlled trial. Ann Surg 2019; 269: 48-52.

Authors: Barth R, Mills J, Suriawinata A, Putra J, Tosteson TD, Axelrod D et al.

Scientific Surgery

Antiviral therapy reduces hepatocellular carcinoma recurrence in patients with low HBV-DNA levels. A randomized controlled trial. Ann Surg 2018: 268: 943-954.

Authors: Huang G, Li P-P, Lau WY, Pan Z-Y, Zhao L-H, Wang Z-G et al.

Scientific Surgery

Open transversus abdominis plane (MOTAP) catheters reduce opioid requirements and improve pain control following open liver resection: a multicenter, blinded, randomized controlled trial. Ann Surg 2018; 268: 233-240.

Authors: Karanicolas PJ, Cleary S, McHardy P, Kiss A, Sawyer J, Behman R et al.

Scientific Surgery

Laparoscopic versus open hepatic resection for solitary hepatocellular carcinoma less than 5cm in cirrhotic patients: a randomized controlled study. J Lap Endosc Adv Surg Tech A 2018; 28: 302-310.

Authors: El-Gendi A, El-Shafei M, El-Gendi S, Shawky A

Scientific Surgery

ALPPS improves resectability compared with conventional two-stage hepatectomy in patients with advanced colorectal liver metastasis: results from a Scandinavian multicenter randomized controlled trial (LIGRO Trial). Ann Surg 2018; 267: 833-840.

Authors: Sandström P, Røsok B, Sparrelid E, Larsen P, Larsson A, Lindell G et al.

Scientific Surgery

Radiofrequency ablation using a 10‐mm target margin for small hepatocellular carcinoma in patients with liver cirrhosis: A prospective randomized trial. J Surg Oncol 2017; 115: 971-979.

Scientific Surgery

Laparoscopic versus open resection for colorectal liver metastases: The OSLO-COMET Randomized Controlled Trial. Ann Surg 2018; 267: 199-207.

Authors: Fretland ÅA, Dagenborg VJ, Bjørnelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW et al.

Scientific Surgery

Partial clamping of the infrahepatic inferior vena cava for blood loss reduction during anatomic liver resection: a prospective, randomized, controlled trial. Surgery 2017; 161: 1502-1513.

Authors: Ueno M, Kawai M, Hayami S, Hirono S, Okada K-I, Uchiyama K et al.

Scientific Surgery

Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial. J Natl Cancer Inst 2017; 109. doi: 10.1093/jnci/djx015.

Authors: Ruers T, Van Coevorden F, Punt CJA, Pierie J-PEN, Borel-Rinkes I, Ledermann JA et al.

Scientific Surgery

Continuous wound infiltration versus epidural analgesia after hepato-pancreatoibiliary surgery (POP-UP): a randomised controlled open-label, non-inferiority trial. Lancet Gastroenterol Hepatol 2016; 1: 105-113.

Authors: Mungroop TH, Veelo DP, Busch OR, van Gulik TM, Karsten TM, de Castro SM et al.

Scientific Surgery

Effect of N-acetylcysteine on liver recovery after resection: A randomized clinical trial. J Surg Oncol 2016; 114: 446–450.

Authors: Grendar J, Ouellet JF, McKay A, Sutherland FR, Bathe OF, Ball CG et al.

Scientific Surgery

Fibrin sealant patch (TachoSil) vs oxidized regenerated cellulose patch (Surgicel Original) for the secondary treatment of local bleeding in patients undergoing hepatic resection: a randomized controlled trial. J Am Coll Surg 2012; 222: 261-268.

Authors: Genyk Y, Kato T, Pomposelli JJ, Wright Jr JK, Sher LS, Tetens V et al.

Scientific Surgery

Fibrin sealant with polyglycolic acid felt vs fibrinogen-based collagen fleece at the liver cut surface for prevention of postoperative bile leakage and hemorrhage: a prospective, randomized, controlled study. J Am Coll Surg 2016; 222: 59-64.

Authors: Kobayashi S, Takeda Y, Nakahira S, Tsujie M, Shimizu J, Miyamoto A et al.

Scientific Surgery

Randomized clinical control study of locoregional therapy combined with arsenic trioxide for the treatment of hepatocellular carcinoma. Cancer 2015; 121: 2917-2925.

Authors: Wang H, Liu Y, Wang X, Liu D, Sun Z, Chun W et al. et al.

Scientific Surgery

Impact of energy devices during liver parenchymal transection: a multicenter randomized controlled trial. World J Surg 2015; 39: 1543-1549.

Authors: Gotohda N, Yamanaka T, Saiura A, Uesaka K, Hashimoto M, Konishi M et al. et al.

Scientific Surgery

Randomized trials of endoscopic therapy and transjugular intrahepatic portosystemic shunt versus portacaval shunt for emergency and elective treatment of bleeding gastric varices in cirrhosis. Surgery 2015; 157: 1028–1045.

Authors: Orloff MJ, Hye RJ, Wheeler HO, Isenberg JI, Haynes KS, Vaida F et al. et al.

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