Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Efficacy and safety of nonantibiotic outpatient treatment in mild acute diverticulitis (DINAMO-study). A multicentre, randomised, open-label, noninferiority trial. Results from a multicenter randomized controlled trial (HOPE ECD-DBD). Ann Surg 2021; 274: e435-e442.

Authors: Mora-López L, Ruiz-Edo N, Estrada-Ferrer O, Piñana-Campón ML, Labró-Ciurans M, Escuder-Perez J et al.

Scientific Surgery

Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 569-577.

Authors: Park JW, Kang S-B, Hao J, Lim S-B, Choi HS, Kim D-W et al.

Scientific Surgery

Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. A phase 2 randomized clinical trial. JAMA Surg 2021; 156: 710-720.

Authors: Rovers KP, Bakkers C, Nienhuijs SW, Burger JWA, Creemers G-JM, Thijs AMJ et al.

Scientific Surgery

A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

Authors: Kemeny NE, Chou JF, Capanu M, Chatila WK, Shi H, Sanchez-Vega F et al.

Scientific Surgery

Surgical management of idiopathic perianal fistulas: a systematic review and meta-analysis. Dig Surg 2021; 38: 104-119.

Authors: Cheung XC, Fahey T, Rogers AC, Pemberton JH, Kavanagh DO

Scientific Surgery

Feasibility and safety of laparoscopic complete mesocolic excision (CME) for right-sided colon cancer. Short-term Outcomes. A Randomized Clinical Study. Ann Surg 2021; 274: 57-62.

Authors: Di Buono G , Buscemi S, Cocorullo G, Sorce V, Amato G, Bonventre G et al.

Scientific Surgery

Early versus late preventive ileostomy closure following colorectal surgery: systematic review and meta-analysis with trial sequential analysis of randomized controlled trials. Dis Colon Rectum 2021; 64: 128-137.

Authors: Cheng Z, Dong S, Bi D, Wang Y, Dai Y, Zhang XM et al.

Scientific Surgery

Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

Authors: Zhu D, Xia J, Gu Y, Lin J, Ding K, Zhou B et al.

Scientific Surgery

Long-term outcomes of a randomized controlled trial of single-incision versus multi-port laparoscopic colectomy for colon cancer. Ann Surg 2021; 273: 1060-1065.

Authors: Watanabe J, Ishibe A, Suwa H, Ota M, Fujii S, Kubota K et al.

Scientific Surgery

Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.

Authors: Santos A, Mentula P, Pinta T, Ismael S, Rautio T, Juusela R et al.

Scientific Surgery

Laparoscopic lavage vs primary resection for acute perforated diverticulitis. Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156: 121-127.

Authors: Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H et al.

Scientific Surgery

Impact of facilitation of early mobilization on postoperative pulmonary outcomes after colorectal surgery. A randomized controlled trial. Ann Surg 2021; 273: 868-875.

Authors: Balvardi S, Pecorelli N, Castelino T, Niculiseanu P, Alhashemi M, Liberman AS et al.

Scientific Surgery

Methods of colostomy construction: no effect on parastomal hernia rate. Results from Stoma-const—a randomized controlled trial. Ann Surg 2021; 273: 640-647.

Authors: Marinez C, Bock D, Erestam S, Engström A, Kälebo P, Nielsen Y et al.

Scientific Surgery

Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer. The CALGB/SWOG 80702 (Alliance) randomized clinical trial. JAMA 2021; 325: 1277-1286.

Authors: Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T et al.

Scientific Surgery

A multicenter randomized controlled trial comparing safety, efficacy, and cost-effectiveness of the Surgisis Anal Fistula Plug versus surgeon’s preference for trans sphincteric fistula-in-ano. The FIAT Trial. Ann Surg 2021; 273: 433-441.

Authors: Jayne D, Scholefield J, Tolan D, Gray R, Senapati A, Hulme CT et al.

Scientific Surgery

Colonic J-pouch or straight colorectal reconstruction after low anterior resection for rectal cancer: impact on quality of life and bowel function: a multicenter prospective randomized study. Dis Colon Rectum 2020; 63: 1511-1523.

Authors: Gavaruzzi T, Pace U, Giandomenico F, Pucciarelli S, Bianco F, Selvaggi F et al.

Scientific Surgery

Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum 2020; 63: 988-999.

Authors: Hajibandeh S, Hajibandeh S, Maw A

Scientific Surgery

Prospectively randomized controlled trial on damage control surgery for perforated diverticulitis with generalized peritonitis. World J Surg 2020; 44: 4098-4105.

Authors: Kafka-Ritsch R, Zitt M, Perathoner A, Gasser E, Kaufman C, Czipin S et al.

Scientific Surgery

Preoperative oral antibiotics and surgical-site infections in colon surgery (ORALEV): a multicentre, single-blind, pragmatic, randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 729-738.

Authors: Basany EE, Solis-Pena A, Pellino G, Kreisler E, Fraccalvieri D, Muinelo-Lorenzo M et al.

Scientific Surgery

Short-term outcomes of single-port versus multiport laparoscopic surgery for colon cancer. The SIMPLE multicenter randomized clinical trial. Ann Surg 2021; 273: 217-223.

Authors: Lee YS, Kim JH, Kim HJ, Lee SC, Kang BM, Kim CW et al.

Scientific Surgery

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open label, phase 3 trial. Lancet Oncol 2021; 22: 256-266.

Authors: Quenet F, Elias D, Roca L, Goere D, Ghouti L, Pocard M et al.

Scientific Surgery

Two-stage Turnbull-Cutait pull-through coloanal anastomosis for low rectal cancer. A randomized clinical trial. JAMA Surg 2020; 155: e201625.

Authors: Biondo S, Trenti L, Espin E, Bianco F, Barrios O, Falato A et al.

Scientific Surgery

Prospective, randomized study on the use of prosthetic mesh to prevent a parastomal hernia in a permanent colostomy: results of a long-term follow-up. Dis Colon Rectum 2020; 63: 678-684.

Authors: Mäkäräinen-Uhlbäck EJ, Klintrup KHB, Vierimaa MT, Carpelan-Holmström MA, Kössi JAO, Kairaluoma MV et al.

Scientific Surgery

Heated fennel therapy promotes the recovery of gastrointestinal function in patients after complex abdominal surgery: A single-center prospective randomized controlled trial in China. Surgery 2020; 168: 793-799.

Authors: Chen B, He Y, Xiao Y, Guo D, Liu P, He Y et al.

Scientific Surgery

Minimal open hemorrhoidectomy versus transanal hemorrhoidal dearterialization: the effect on symptoms: an open-label randomized controlled trial. Dis Colon Rectum 2020; 63: 655-667.

Authors: Rørvik H, Campos AH, Styr K, Ilum L, McKinstry GK, Brandstrup B et al.

Scientific Surgery

Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 2020; 21: 1620-1629.

Authors: Andre T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I et al.

Scientific Surgery

Long-term oncologic results after stenting as a bridge to surgery versus emergency surgery for malignant left-sided colonic obstruction. A multicenter randomized controlled trial (ESCO Trial). Ann Surg 2020; 272: 703-708.

Authors: Arezzo A, Forcignanò E, Bonino MA, Balagué C, Targarona E, Borghi F et al.

Scientific Surgery

Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer. A randomized clinical trial. JAMA Surg 2020; 155: 233-242.

Authors: Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M et al.

Scientific Surgery

Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADE-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol 2020; 5: 343-351.

Authors: Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C et al.

Scientific Surgery

Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial. Lancet Gastroenterol Hepatol 2020; 5: 465-474.

Authors: Rullier E, Vendrely V, Rouanet P, Tuech JJ, Valverde A

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