Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

Authors: Kemeny NE, Chou JF, Capanu M, Chatila WK, Shi H, Sanchez-Vega F et al.

Scientific Surgery

Feasibility and safety of laparoscopic complete mesocolic excision (CME) for right-sided colon cancer. Short-term Outcomes. A Randomized Clinical Study. Ann Surg 2021; 274: 57-62.

Authors: Di Buono G , Buscemi S, Cocorullo G, Sorce V, Amato G, Bonventre G et al.

Scientific Surgery

Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

Authors: Zhu D, Xia J, Gu Y, Lin J, Ding K, Zhou B et al.

Scientific Surgery

Long-term outcomes of a randomized controlled trial of single-incision versus multi-port laparoscopic colectomy for colon cancer. Ann Surg 2021; 273: 1060-1065.

Authors: Watanabe J, Ishibe A, Suwa H, Ota M, Fujii S, Kubota K et al.

Scientific Surgery

Impact of facilitation of early mobilization on postoperative pulmonary outcomes after colorectal surgery. A randomized controlled trial. Ann Surg 2021; 273: 868-875.

Authors: Balvardi S, Pecorelli N, Castelino T, Niculiseanu P, Alhashemi M, Liberman AS et al.

Scientific Surgery

Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer. The CALGB/SWOG 80702 (Alliance) randomized clinical trial. JAMA 2021; 325: 1277-1286.

Authors: Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T et al.

Scientific Surgery

Preoperative oral antibiotics and surgical-site infections in colon surgery (ORALEV): a multicentre, single-blind, pragmatic, randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 729-738.

Authors: Basany EE, Solis-Pena A, Pellino G, Kreisler E, Fraccalvieri D, Muinelo-Lorenzo M et al.

Scientific Surgery

Short-term outcomes of single-port versus multiport laparoscopic surgery for colon cancer. The SIMPLE multicenter randomized clinical trial. Ann Surg 2021; 273: 217-223.

Authors: Lee YS, Kim JH, Kim HJ, Lee SC, Kang BM, Kim CW et al.

Scientific Surgery

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open label, phase 3 trial. Lancet Oncol 2021; 22: 256-266.

Authors: Quenet F, Elias D, Roca L, Goere D, Ghouti L, Pocard M et al.

Scientific Surgery

Prospective, randomized study on the use of prosthetic mesh to prevent a parastomal hernia in a permanent colostomy: results of a long-term follow-up. Dis Colon Rectum 2020; 63: 678-684.

Authors: Mäkäräinen-Uhlbäck EJ, Klintrup KHB, Vierimaa MT, Carpelan-Holmström MA, Kössi JAO, Kairaluoma MV et al.

Scientific Surgery

Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 2020; 21: 1620-1629.

Authors: Andre T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I et al.

Scientific Surgery

Long-term oncologic results after stenting as a bridge to surgery versus emergency surgery for malignant left-sided colonic obstruction. A multicenter randomized controlled trial (ESCO Trial). Ann Surg 2020; 272: 703-708.

Authors: Arezzo A, Forcignanò E, Bonino MA, Balagué C, Targarona E, Borghi F et al.

Scientific Surgery

Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer. A randomized clinical trial. JAMA Surg 2020; 155: 233-242.

Authors: Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M et al.

Scientific Surgery

Prophylactic intra-abdominal drainage following colorectal anastomoses. A systematic review and meta-analysis of randomized controlled trials. Am J Surg 2020; 219: 164-174.

Authors: Podda M, Di Saverio S, Davies JR, Atzeni J, Balestra F, Virdis F et al.

Scientific Surgery

Simple versus complex preoperative carbohydrate drink to preserve perioperative insulin sensitivity in laparoscopic colectomy. A randomized controlled trial. Ann Surg 2020; 271: 819-826

Authors: Karimian N, Kaneva P, Donatelli F, Stein B, Liberman AS, Charlebois P et al.

Scientific Surgery

Perioperative FOLFOX 4 versus FOLFOX 4 plus Cetuximab versus immediate surgery for high-risk stage II and III colon cancers. A phase II multicenter randomized controlled trial (PRODIGE 22). Ann Surg 2020; 271: 637-645

Authors: Karoui M, Rullier A, Piessen G, Legoux JL, Barbier E, De Chaisemartin C et al.

Scientific Surgery

Early versus standard closure of temporary ileostomy in patients with rectal cancer: a randomized controlled trial. J Surg Oncol 2019; 120: 249-299

Authors: Kuliavas J, Dulskas A, Kryzauskas M, Pauza K, Kilius A, Rudinskaite G et al.

Scientific Surgery

Quality of life after curative resection for rectal cancer in patients treated with adjuvant chemotherapy compared with observation: results of the randomized phase III SCRIPT Trial. Dis Colon Rectum 2019; 62: 711-720

Authors: van der Valk MJ, Hilling DE, Meershoek-Klein Kranenbarg E, Peeters K, Kapiteijn E, Tsonaka R et al.

Scientific Surgery

Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis. BMJ Open 2019; 9: e032773

Authors: Jodal HC, Helsingen LM, Anderson JC, Lytvyn L, Vandvik PO, Emilsson L et al.

Scientific Surgery

Intracorporeal or extracorporeal ileocolic anastomosis after laparoscopic right colectomy. A double-blinded randomized controlled trial. Ann Surg 2019; 270: 762-767.

Authors: Allaix M, Degiuli M, Bonino MA, Arezzo A, Mistrangelo M, Passera R et al.

Scientific Surgery

Does a longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer? Three years’ follow-up results of the Greccar-6 randomized multicenter trial. Ann Surg 2019; 270: 747-754

Authors: Lefèvre J, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C et al.

Scientific Surgery

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicenter, open-label, randomized trial. Lancet Gastroenterol Hepatol 2019; 4: 761-770

Authors: Klaver CEL, Wisselink DD , Punt CJA , Snaebjornsson P , Crezee J, Aalbers AG et al.

Scientific Surgery

Effect of a single aspirin dose prior to fecal immunochemical testing on test sensitivity for detecting advanced colorectal neoplasms. A randomized clinical trial. JAMA 2019; 321: 1686-1692.

Authors: Brenner H, Calderazzo S, Seufferlein T, Ludwig L, Dikopoulos N, Mangold J et al.

Scientific Surgery

Disease-free survival and local recurrence after laparoscopic-assisted resection or open resection for rectal cancer. The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial. Ann Surg 2019; 269: 596-602.

Authors: Stevenson ARL, Solomon M, Brown CSB, Lumley JW, Hewett P, Clouston A et al.

Scientific Surgery

Disease-free survival and local recurrence for laparoscopic resection compared with open resection of stage II to III rectal cancer. Follow-up results of the ACOSOG Z6051 randomized controlled trial. Ann Surg 2019; 269: 589-595.

Authors: Fleshman J, Branda ME, Sargent DJ, Boller AM, George VV, Abbas MA et al.

Scientific Surgery

Intraperitoneal local anesthetic instillation and postoperative infusion improves functional recovery following colectomy. A randomized controlled trial. Dis Colon Rectum 2018; 61: 1205-1216.

Authors: Duffield JA, Thomas ML, Moore JW, Hunter RA, Wood C, Gentili S et al.

Scientific Surgery

Liposomal bupivacaine transversus abdominis plane block versus epidural analgesia in a colon and rectal surgery enhanced recovery pathway. A randomized clinical trial. Dis Colon Rectum 2018; 61: 1196-1204.

Authors: Felling DR, Jackson MW, Ferraro J, Battaglia MA, Albright JJ, Wu J et al.

Scientific Surgery

The ALCCaS Trial: a randomized controlled trial comparing quality of life following laparoscopic versus open colectomy for colon cancer. Dis Colon Rectum 2018; 61: 1156-1162.

Authors: McCombie AM, Frizelle F, Bagshaw PF, Frampton CM, Hewett PJ, McMurrick PJ et al.

Scientific Surgery

Enhanced recovery protocols for adults undergoing colorectal surgery. A systematic review and meta-analysis. Dis Colon Rectum 2018; 61: 1108-1118.

Authors: Greer NL, Gunnar WP, Dahm P, Lee AE, MacDonald R, Shaukat A et al.

Scientific Surgery

Bowel obstruction and ventral hernia after laparoscopic versus open surgery for rectal cancer in a randomized trial (COLOR II). Ann Surg 2019; 269: 53-57.

Authors: Petersson J, Koedam TW, Bonjer HJ, Andersson J, Angenete E, Bock D et al.

Older Entries