Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma. The NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.

Authors: Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z et al.

Scientific Surgery

Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer. A randomized clinical trial. JAMA Surg 2021; 156: 601-610.

Authors: Van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F et al.

Scientific Surgery

Morbidity and mortality of patients who underwent minimally invasive esophagectomy after neoadjuvant chemo-radiotherapy vs neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma. A randomized clinical trial. JAMA Surg 2021; 156: 444-451.

Authors: Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y et al.

Scientific Surgery

Five-year survival outcomes of hybrid minimally invasive esophagectomy in esophageal cancer. Results of the MIRO Randomized Clinical Trial. JAMA Surg 2021; 156: 323-332.

Authors: Nuytens F, Dabakuyo-Yonli TS, Meunier B, Gagnière J, Collet D, D’Journo XB et al.

Scientific Surgery

Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 292-303.

Authors: Adamson DA, Byrne A, Porter C, Blazeby J, Griffiths G, Nelson A et al.

Scientific Surgery

Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med 2021; 384: 1191-1203.

Authors: Kelly RJ, Ajani JA, Kuzdzal J, Zander T, van Cutsem E, Piessen G et al.

Scientific Surgery

Surgical morbidity and mortality from the multicenter randomized controlled NeoRes II Trial. Standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for esophageal cancer. Ann Surg 2020; 272: 684-689.

Authors: Nilsson K, Klevebro F, Rouvelas I, Lindblad M, Szabo E, Halldestam I et al.

Scientific Surgery

Randomized comparison of gastric tube reconstruction with and without duodenal diversion plus Roux-en-Y anastomosis after esophagectomy. Ann Surg 2020; 272: 48-54.

Authors: Yano M, Sugimura K, Miyata H, Motoori M, Tanaka K, Omori T et al.

Scientific Surgery

Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer. Analysis of a multicenter, open-label, randomized phase III controlled trial. The MIRO Trial. Ann Surg 2020; 271: 1023-1029.

Authors: Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.

Scientific Surgery

Survival outcomes after laparoscopy-assisted distal gastrectomy versus open gastrectomy with nodal dissection for clinical stage 1A or 1B gastric cancer (JCOG0912): a multicenter, non-inferiority, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Katai H, Mizusawa J, Katayama H, Morita S, Yamada T, Brando E et al.

Scientific Surgery

Assessment of laparoscopic distal gastrectomy after neoadjuvant chemotherapy for locally advanced gastric cancer. A randomized clinical trial. JAMA Surg 2019; 154: 1093-1101

Authors: Li Z, Shan F, Ying X, Zhang Y, E J-Y, Wang Y et al.

Scientific Surgery

Family history of gastric cancer and Helicobacter pylori treatment. N Engl J Med 2020; 382: 427-436

Authors: Choi IJ, Kim CG, Lee JY, Kim Y-I, Kook M-C, Park B et al.

Scientific Surgery

Direct oral feeding following minimally invasive esophagectomy (NUTRIENT II trial). An international, multicenter, open-label randomized controlled trial. Ann Surg 2020; 271: 41-47

Authors: Berkelmans GH, Fransen LFC, Dolmans-Zwartjes ACP, Kouwenhoven EA, van Det MJ, Nilsson M et al.

Scientific Surgery

Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg 20129; 270: 983-991

Authors: Lee H-J, Hyung WJ, Yang H-K, Han S, Park Y-K, An JY et al.

Scientific Surgery

Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally advanced gastric cancer. The SEIPLUS randomized clinical trial. JAMA Surg 2019; 154: 610-616

Authors: Guo J, Xu A, Sun X, Zhao X, Xia Y, Rao H et al.

Scientific Surgery

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019; 393: 1948-1957.

Authors: Al-Batran S-E, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S et al.

Scientific Surgery

Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer. A randomized controlled trial. Ann Surg 2019; 269: 621-630.

Authors: van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens L, Joore HC et al.

Scientific Surgery

Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery. A randomized clinical trial. JAMA Surg 2018; 153: 1081-1089.

Authors: Minnella EM, Awasthi R, Loiselle S-E, Agnihotram RV, Ferri LE, Carli F et al.

Scientific Surgery

Hybrid minimally invasive esophagectomy for esophageal cancer. N Engl J Med 2019; 380: 152-162.

Authors: Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.

Scientific Surgery

Neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced squamous cell carcinoma of the esophagus (NEOCRTEC5010): a phase III multicenter, randomized, open-label clinical trial. J Clin Oncol 2018; 36: 2796-2803.

Authors: Yang H, Liu Y, Chen Y, Zhu C, Fang W, Yu Z et al.

Scientific Surgery

The RESTORE randomized controlled trial: impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship. Ann Surg 2008; 268: 747-755.

Authors: O’Neill L, Guinan E, Doyle S, Bennett AE, Murphy C, Elliott JA et al.

Scientific Surgery

Extended right thoracic approach compared with limited left thoracic approach for patients with middle and lower esophageal squamous cell carcinoma: three-year survival of a prospective, randomized, open-label trial. Ann Surg 2018; 267: 826-832.

Authors: Li B, Hu H, Zhang Y, Zhang J, Miao L, Ma L et al.

Scientific Surgery

Early oral feeding following McKeown minimally invasive esophagectomy: an open-label, randomized, controlled, noninferiority trial. Ann Surg 2018; 267: 435-442.

Authors: Sun H-B, Li Y, Liu X-B, Zhang R-X, Wang Z-F, Lerut T et al.

Scientific Surgery

Predictors of overall and recurrence-free survival after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma: Pooled analysis of individual patient data (IPD) from randomized controlled trials (RCTs). EJSO 2017; 43: 1550-1558.

Authors: Ronellenfitsch U, Schwarzbach M, Hofheinz R, Kienle P, Nowak K, Kieser M et al.

Scientific Surgery

Circular stapling versus triangulating stapling for the cervical esophagogastric anastomosis after esophagectomy in patients with thoracic esophageal cancer: A prospective, randomized, controlled trial. Surgery 2017; 162: 131-138.

Authors: Hayata K, Nakamori M, Nakamura M, Ojima T, Iwahashi M, Katsuda M et al.

Scientific Surgery

Does prolonged enteral feeding with supplemental omega-3 fatty acids impact on recovery post-esophagectomy: results of a randomized double-blind trial. Ann Surg 2017; 266: 720-728.

Authors: Healy LA, Ryan A, Doyle S, Ní Bhuachalla EB, Cushen S, Segurado R et al.

Scientific Surgery

Minimally invasive versus open esophageal resection: three-year follow-up of the previously reported randomized controlled trial: The TIME Trial. Ann Surg 2017; 266: 232-236.

Authors: Straatman J, van der Wielen N, Cuesta MA, Daams F, Roig Garcia J, Bonavina L et al.

Scientific Surgery

Survival after neoadjuvant and adjuvant treatments compared to surgery alone for resectable esophageal carcinoma: a network meta-analysis. Ann Surg 2017; 265: 481-491.

Authors: Pasquali S, Yim G, Vohra R , Mocellin S, Nyanhongo D, Marriott P et al.

Scientific Surgery

Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial. Lancet Oncol 2017; 18: 357-370.

Authors: Cunningham D, Stenning SP , Smyth EC, Okines AF, Allum WH, Rowley S et al.

Scientific Surgery

Randomized controlled study to evaluate the efficacy of a preoperative respiratory rehabilitation program to prevent postoperative pulmonary complications after esophagectomy. Dig Surg 2015; 32: 331-337.

Authors: Yamana I, Takeno S, Hashimoto T, Maki K, Shibata R, Shiwaku H et al. et al.

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