Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis. Lancet Gastro Hepatol 2021; 9: 733-742.

Authors: Akshintala VS, Weiland CJS, Bhullar FA, Kamal A, Kanthasamy K, Kuo A et al.

Scientific Surgery

Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.

Authors: Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL et al.

Scientific Surgery

Immediate oral refeeding in patients with mild and moderate acute pancreatitis. A multicenter, randomized controlled trial (PADI trial). Ann Surg 2021; 274: 255-263.

Authors: Ramírez-Maldonado E, Gordo SL, Pueyo EM, Sánchez-García A, Mayol S, González S et al.

Scientific Surgery

Safety of combined division vs separate division of the splenic vein in patients undergoing distal pancreatectomy. A noninferiority randomized clinical trial. JAMA Surg 2021; 156: 418-428.

Authors: Yamada S, Fujii T, Sonohara F, Kawai M, Shibuya K, Matsumoto I et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.

Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.

Scientific Surgery

A systematic review and network-meta-analysis of gastro-enteric reconstruction techniques following pancreatoduodenectomy to reduce delayed gastric emptying. World J Surg 2020; 44: 2314-2322.

Authors: Kamarajah SK, Bundred JR, Alessandri G, Robinson SM, Wilson CH, French JJ et al.

Scientific Surgery

Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis. A single-center, phase 3, randomized clinical trial. JAMA Surg 2020; 155: 313-321.

Authors: Andrianello S, Marchegiani G, Malleo G, Masini G, Balduzzi A, Paiella S et al.

Scientific Surgery

Effect of hydrocortisone vs pasireotide on pancreatic surgery complications in patients with high risk of pancreatic fistula. A randomized clinical trial. JAMA Surg 2020; 155: 291-298.

Authors: Tarvainen T, Siren J, Kokkola A, Sallinen V

Scientific Surgery

Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020; 396: 167-176.

Authors: Schepers NJ, Hallensleben NDL, Besselink MG, Anten M-PG, Bollen TL, da Costa DW et al.

Scientific Surgery

Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomized controlled trials. J Clin Med. 2020; 9: 1129.

Authors: Cloyd JM, Heh V, Pawlik TM, Ejaz A, Dillhoff M, Tsung A et al.

Scientific Surgery

Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247

Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.

Scientific Surgery

Gallstone pancreatitis: admission versus normal cholecystectomy—a randomized trial (Gallstone PANC Trial). Ann Surg 2019; 270: 519-527

Authors: Mueck K, Wei S , Pedroza C , Bernardi K , Jackson ML , Liang MK et al.

Scientific Surgery

Results of a randomized controlled trial comparing closed-suction drains versus passive gravity drains after pancreatic resection. Surgery 2018; 164: 1057-1063.

Authors: Čečka F, Jon B, Skalický P, Čermáková E, Neoral C, Loveček M et al.

Scientific Surgery

Modified Blumgart mattress suture versus conventional interrupted suture in pancreaticojejunostomy during pancreaticoduodenectomy. Randomized controlled trial. Ann Surg 2019; 269: 243–251.

Authors: Hirono S, Kawai M, Okada K-I, Miyazawa M, Kitahata Y, Hayami S et al.

Scientific Surgery

FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Engl J Med 2018; 379: 2395-2406.

Authors: Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC, Raoul J-L et al.

Scientific Surgery

Minimally invasive versus open distal pancreatectomy (LEOPARD). A multicenter patient-blinded randomized controlled trial. Ann Surg 2019; 269: 2-9.

Authors: de Rooij T, van Hilst J, van Santvoort H, Boerma D, van den Boezem P, Daams F et al.

Scientific Surgery

Comparison of perioperative outcomes between laparoscopic and open approach for pancreatoduodenectomy: the PADULAP randomized controlled trial. Ann Surg 2018; 268: 731-739.

Authors: Poves I, Burdío F, Morató O, Iglesias M, Radosevic A, Ilzarbe L et al.

Scientific Surgery

Pancreaticojejunostomy: Does the technique matter? A randomized trial. J Surg Oncol 2018; 117: 389-396.

Authors: Singh AN, Pal S, Mangla V, Kilambi R, George J, Dash NR et al.

Scientific Surgery

Efficacy of a dual-ring wound protector for prevention of surgical site infections after pancreaticoduodenectomy in patients with intrabiliary stents: a randomized clinical trial. Ann Surg 2018; 268: 35-40.

Authors: Bressan A, Aubin J-M, Martel G, Dixon E, Bathe O, Sutherland F et al.

Scientific Surgery

Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2/3 trial. Ann Surg 2018; 268: 215-222.

Authors: Jang J-Y, Han Y, Lee H, Kim S-W, Kwon W, Lee K-H et al.

Scientific Surgery

Pylorus resection does not reduce delayed gastric emptying after partial pancreatoduodenectomy: a blinded randomized controlled trial (PROPP Study, DRKS00004191). Ann Surg 2018; 267: 1021-1027.

Authors: Hackert T, Probst P, Knebel P, Doerr-Harim C, Bruckner T, Klaiber U et al.

Scientific Surgery

CONKO-005: Adjuvant chemotherapy with gemcitabine plus erlotinib versus gemcitabine alone in patients after R0 resection of pancreatic cancer: a multicenter randomized phase III trial. J Clin Oncol 2017; 35: 3330-3337.

Authors: Sinn M, Bahra M, Liersch T, Gellert K, Messmann H, Bechstein W et al.

Scientific Surgery

Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-2032.

Authors: Van Dijk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ et al.

Scientific Surgery

Does Braun anastomosis have an impact on the incidence of delayed gastric emptying and the extent of intragastric bile reflux following pancreatoduodenectomy? A randomized controlled study. Dig Surg 2017; 34: 462-468.

Authors: Fujieda H, Yokoyama Y, Hirata A, Usui H, Sakatoku Y, Fukaya M et al.

Scientific Surgery

Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018; 391: 51–58.

Authors: Van Brunschot S, van Grinsven J, van Santvoort HC, Bakker OJ, Besselink MG, Boermeester MA et al.

Scientific Surgery

A Prospective randomized multicenter trial of distal pancreatectomy with and without routine intraperitoneal drainage. Ann Surg 2017; 266: 421-431.

Authors: Van Buren G , Bloomston M, Schmidt CR, Behrman SW, Zyromski NJ, Ball C et al.

Scientific Surgery

Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet 2017; 390: 1027–1037.

Authors: Diener MK, Hüttner FJ, Keiser M, Knebel P, Dörr-Harim C, Distler M et al.

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