Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

Authors: Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger TS, Kranke P et al.

Scientific Surgery

Effect of a predictive model on planned surgical duration accuracy, patient wait time, and use of presurgical resources. A randomized clinical trial. JAMA Surg 2021; 156 :315-321.

Authors: Strömblad CT, Baxter-King R, Meisami A, Yee S-J, Levine MR, Ostrovsky A et al.

Scientific Surgery

Early corticosteroid cessation vs long-term corticosteroid therapy in kidney transplant recipients. Long-term outcomes of a randomized clinical trial. JAMA Surg 2021; 156: 307-314.

Authors: Woodle ES, Gill JS, Clark S, Stewart D, Alloway R, First R et al.

Scientific Surgery

Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. N Engl J Med 2021; 384: 2394-2405.

Authors: Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P et al.

Scientific Surgery

Intermittent pneumatic compression in addition to standard prophylaxis of postoperative venous thromboembolism in extremely high-risk patients (IPC SUPER): a randomized controlled trial. Ann Surg 2021; 274: 63-69.

Authors: Lobastov K, Sautina E, Alencheva E, Bargandzhiya A, Schastlivtsev I, Barinov V et al.

Scientific Surgery

A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication. J Vasc Surg 2021; 73: 1750-8.

Authors: Hoel H, Pettersen EM, Øivind Høiseth L, Mathiesen I, Seternes A, Hisdal J et al.

Scientific Surgery

Surgical management of idiopathic perianal fistulas: a systematic review and meta-analysis. Dig Surg 2021; 38: 104-119.

Authors: Cheung XC, Fahey T, Rogers AC, Pemberton JH, Kavanagh DO

Scientific Surgery

Feasibility and safety of laparoscopic complete mesocolic excision (CME) for right-sided colon cancer. Short-term Outcomes. A Randomized Clinical Study. Ann Surg 2021; 274: 57-62.

Authors: Di Buono G , Buscemi S, Cocorullo G, Sorce V, Amato G, Bonventre G et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Five-year survival outcomes of hybrid minimally invasive esophagectomy in esophageal cancer. Results of the MIRO Randomized Clinical Trial. JAMA Surg 2021; 156: 323-332.

Authors: Nuytens F, Dabakuyo-Yonli TS, Meunier B, Gagnière J, Collet D, D’Journo XB et al.

Scientific Surgery

Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 292-303.

Authors: Adamson DA, Byrne A, Porter C, Blazeby J, Griffiths G, Nelson A et al.

Scientific Surgery

Robotic versus laparoscopic ventral hernia repair. One-year results from a prospective, multicenter, blinded randomized controlled trial. Ann Surg 2021; 273: 1076-1080.

Authors: Dhanani N, Olavarria O, Holihan J, Shah S, Wilson T, Loor M et al.

Scientific Surgery

Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss and quality of life at 7 Years in patients with morbid obesity. The SLEEVEPASS randomized clinical trial. JAMA Surg 2021; 156: 137-146.

Authors: Gronroos S, Helmio M, Juuti A, Tiusanen R, Hurme S, Loyttyniemi E et al.

Scientific Surgery

Effect of cognitive prehabilitation on the incidence of postoperative delirium among older adults undergoing major noncardiac surgery. The Neurobics randomized clinical trial. JAMA Surg 2021; 156: 148-156.

Authors: Humeidan ML, Reyes J-PC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan C et al.

Scientific Surgery

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 120-127.

Authors: Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW et al.

Scientific Surgery

Impact of mesh and fixation on chronic inguinal pain in Lichtenstein hernia repair: 5-year outcomes from the Finn Mesh Study. World J Surgery 2021; 45: 459–464.

Authors: Matikainan M, Vironen J, Kossi J, Hulmi T, Hertsi M, Rantanen T et al.

Scientific Surgery

Prophylactic single-use negative pressure dressing in closed surgical wounds after incisional hernia repair. A randomized, controlled trial. Ann Surg 2021; 273: 1081-1086.

Authors: Bueno-Lledó J, Franco-Bernal A, Garcia-Voz-Mediano MT, Torregrosa-Gallud A, Bonafé S

Scientific Surgery

Early versus late preventive ileostomy closure following colorectal surgery: systematic review and meta-analysis with trial sequential analysis of randomized controlled trials. Dis Colon Rectum 2021; 64: 128-137.

Authors: Cheng Z, Dong S, Bi D, Wang Y, Dai Y, Zhang XM et al.

Scientific Surgery

Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

Authors: Zhu D, Xia J, Gu Y, Lin J, Ding K, Zhou B et al.

Scientific Surgery

Long-term outcomes of a randomized controlled trial of single-incision versus multi-port laparoscopic colectomy for colon cancer. Ann Surg 2021; 273: 1060-1065.

Authors: Watanabe J, Ishibe A, Suwa H, Ota M, Fujii S, Kubota K et al.

Scientific Surgery

Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.

Authors: Santos A, Mentula P, Pinta T, Ismael S, Rautio T, Juusela R et al.

Scientific Surgery

Laparoscopic lavage vs primary resection for acute perforated diverticulitis. Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156: 121-127.

Authors: Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H et al.

Scientific Surgery

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021; 397: 2253-2263.

Authors: Lopes RD, de barros e Silva PGM, Furtado RHM, Macedo AVS, Bronhara B, Damiani LP et al.

Scientific Surgery

Dexamethasone and surgical-site infection. N Engl J Med 2021; 384: 1731-1741.

Authors: Corcoran TB, Myles PS, Forbes AB, Cheng AC, Bach LA, O’Loughlin E et al.

Scientific Surgery

Heavyweight mesh is superior to lightweight mesh in laparo-endoscopic inguinal hernia repair. A meta-analysis and trial sequential analysis of randomized controlled trials. Ann Surg 2021; 273: 890-899.

Authors: Bakker W, Aufenacker TJ, Boschman JS, Burgmans JP

Scientific Surgery

Resection of cavity shave margins in stage 0–III breast cancer patients undergoing breast conserving surgery. A prospective multicenter randomized controlled trial. Ann Surg 2021; 273: 876-881.

Authors: Dupont E, Tsangaris T, Garcia-Cantu C, Howard-McNatt M, Chiba A, Berger AC et al.

Scientific Surgery

Impact of facilitation of early mobilization on postoperative pulmonary outcomes after colorectal surgery. A randomized controlled trial. Ann Surg 2021; 273: 868-875.

Authors: Balvardi S, Pecorelli N, Castelino T, Niculiseanu P, Alhashemi M, Liberman AS et al.

Scientific Surgery

Effect of low-intensity vs high-intensity home-based walking exercise on walk distance in patients with peripheral artery disease. The LITE Randomized Clinical Trial. JAMA 2021; 325: 1266-1276.

Authors: McDermott MM, Spring B, Tian L, Treat-Jacobsen D, Ferrucci L, Lloyd-Jones D et al.

Scientific Surgery

Systematic review and meta-analysis of wound adjuncts for the prevention of groin wound surgical site infection in arterial surgery. Eur J Vasc Endovasc Surg 2021; 61: 636-646.

Authors: Gwilym BL, Dovell G, Dattani N, Ambler GK, Shalhoub J, Forsythe RO et al.

Scientific Surgery

Percutaneous access does not confer superior clinical outcomes over cutdown access for endovascular aneurysm repair: meta-analysis and trial sequential analysis of randomised controlled trials. Eur J Vasc Endovasc Surg 2021; 61: 383-394.

Authors: Antoniou GA, Antoniou SA

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