Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer. Analysis of a multicenter, open-label, randomized phase III controlled trial. The MIRO Trial. Ann Surg 2020; 271: 1023-1029.

Authors: Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.

Scientific Surgery

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet 2020; 395: 1927-1936.

Authors: The HALT-IT Trial Collaborators

Scientific Surgery

Non-operative treatment versus appendectomy for acute non-perforated appendicitis in children: five-year follow up of a randomized controlled pilot trial. Ann Surg 2020; 271: 1030-1035.

Authors: Patkova B, Svenningsson A, Almström M, Eaton S, Wester T, Svensson JF et al.

Scientific Surgery

Effect of laparoscopic distal gastrectomy vs open distal gastrectomy on long-term survival among patients with stage I gastric cancer. The KLASS-01 Randomized Clinical Trial. JAMA Oncol 2019; 5: 506-513.

Authors: Kim H-H, Han S-U, Kim M-C, Kim W, Le H-J, Ryu SW et al.

Scientific Surgery

Efficacy of soluble fibre, antispasmodic drugs and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol 2020; 5: 117-131.

Authors: Black CJ, Yuan Y , Selinger CP, Camilleri CP, Quigley EMM, Moayyedi P et al.

Scientific Surgery

Povidone-iodine irrigation for pediatric perforated appendicitis may be protective. A Bayesian pilot randomized controlled trial. Ann Surg 2020; 271: 827-833

Authors: Anderson KT, Putnam LR, Bartz-Kurycki MA, Hamilton EC, Yafi M, Pedroza C et al.

Scientific Surgery

Survival outcomes after laparoscopy-assisted distal gastrectomy versus open gastrectomy with nodal dissection for clinical stage 1A or 1B gastric cancer (JCOG0912): a multicenter, non-inferiority, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Katai H, Mizusawa J, Katayama H, Morita S, Yamada T, Brando E et al.

Scientific Surgery

Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn’s disease: the LIR!C Trial. Gut 2019; 68: 1774-1780

Authors: De Groof EJ, Stevens TW, Eshuis EJ, Gardenbroek TJ, Bosmans JE, van Dongen JM et al.

Scientific Surgery

Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial. Gut 2019; 68: 796-803

Authors: Lau JYW, Pittayanon R, Wong K-T, Pinjaroen N, Chiu PWY, Rerknimitr R et al.

Scientific Surgery

Assessment of laparoscopic distal gastrectomy after neoadjuvant chemotherapy for locally advanced gastric cancer. A randomized clinical trial. JAMA Surg 2019; 154: 1093-1101

Authors: Li Z, Shan F, Ying X, Zhang Y, E J-Y, Wang Y et al.

Scientific Surgery

Family history of gastric cancer and Helicobacter pylori treatment. N Engl J Med 2020; 382: 427-436

Authors: Choi IJ, Kim CG, Lee JY, Kim Y-I, Kook M-C, Park B et al.

Scientific Surgery

Direct oral feeding following minimally invasive esophagectomy (NUTRIENT II trial). An international, multicenter, open-label randomized controlled trial. Ann Surg 2020; 271: 41-47

Authors: Berkelmans GH, Fransen LFC, Dolmans-Zwartjes ACP, Kouwenhoven EA, van Det MJ, Nilsson M et al.

Scientific Surgery

Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children. A systematic review and meta-analysis. Ann Surg 2019; 270: 1028-1040

Authors: Podda M, Gerardi C, Cillara N, Fearnhead N, Gomes CA, Birindelli A et al.

Scientific Surgery

Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg 20129; 270: 983-991

Authors: Lee H-J, Hyung WJ, Yang H-K, Han S, Park Y-K, An JY et al.

Scientific Surgery

Endoscopic or surgical myotomy in patients with idiopathic achalasia. N Engl J Med 2019; 381: 2219-2229

Authors: Werner YB, Hakanson B, Martinek J, Repici A, von Rahden BHA, Bredenoord AJ et al.

Scientific Surgery

Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally advanced gastric cancer. The SEIPLUS randomized clinical trial. JAMA Surg 2019; 154: 610-616

Authors: Guo J, Xu A, Sun X, Zhao X, Xia Y, Rao H et al.

Scientific Surgery

Comparison of laparoscopic 2700 posterior partial fundoplication vs total fundoplication for the treatment of gastroesophageal reflux disease. A randomized clinical trial. JAMA Surg 2019; 154: 479-486

Authors: Håkanson BS, Lundell L, Bylund A, Thorell A

Scientific Surgery

Randomized trial of medical versus surgical treatment for refractory heartburn. N Engl J Med 2019; 381: 1513-1523

Authors: Spechler SJ, Hunter JG, Jones KM, Lee RL, Smith BR, Mashimo H et al.

Scientific Surgery

The effectiveness of contralateral drainage in reducing superficial incisional surgical site infection in loop ileostomy closure: prospective, randomized controlled trial. World J Surg 2019; 43: 1692-1699.

Authors: Serracant A, Serra-Aracil X, Mora-Lopez L, Pallisera-Lloveras A, Serra-Pla S, Zarate-Pinedo A et al.

Scientific Surgery

Pouch versus no pouch following total gastrectomy: meta-analysis of randomized and non-randomized studies. Ann Surg 2019; 269: 1041-1053.

Authors: Syn N, Wee I, Shabbir A, Kim G, So JB-Y

Scientific Surgery

Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging. 1-year outcomes of the Peri–appendicitis Acuta randomized clinical trial. JAMA Surg 2019; 154: 200-207.

Authors: Mällinen J, Rautio T, Grönroos J, Rantanen T, Nordström P, Savolainen H et al.

Scientific Surgery

Effect of laparoscopic vs open distal gastrectomy on 3-year disease-free survival in patients with locally advanced gastric cancer. The CLASS-01 randomized clinical trial. JAMA 2019; 321: 1983-1992.

Authors: Yu J, Huang C, Sun Y, Su X, Cao H, Hu J et al.

Scientific Surgery

A randomized double blinded study to determine the effectiveness of utilizing intraperitoneal bupivacaine: does it reduce postoperative opioid use following laparoscopic appendectomy? Am J Surg 2019; 217: 479-482.

Authors: Sevensma K, Schleichert T, Shwickerath C, Shoemaker A, Miller C

Scientific Surgery

Efficacy of transversus abdominis plane (TAP) block in pain management after laparoscopic sleeve gastrectomy (LSG): A double-blind randomized controlled trial. Am J Surg 2019; 217: 126-132.

Authors: Saber AA, Lee YC, Arjun C, Namik O, Armand A, Al-Ayoubi S et al.

Scientific Surgery

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet 2019; 393: 1948-1957.

Authors: Al-Batran S-E, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S et al.

Scientific Surgery

Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer. A randomized controlled trial. Ann Surg 2019; 269: 621-630.

Authors: van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens L, Joore HC et al.

Scientific Surgery

Efficacy of preoperative oral antibiotic prophylaxis for the prevention of surgical site infections in patients with Crohn’s Disease. A Randomized Controlled Trial. Ann Surg 2019; 269: 420-426.

Authors: Uchino M, Ikeuchi H, Bando T, Chohno T, Sasaki H, Horio Y et al.

Scientific Surgery

Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial. Lancet 2019; 393: 1299-1309.

Authors: Maud R, Espalieu P, Pelascini E, Caiazzo R, Sterkers A, Khamphommala L et al.

Scientific Surgery

Effect of perioperative oral nutritional supplementation in malnourished patients who undergo gastrectomy: a prospective randomized trial. Surgery 2018; 164: 1263-1270.

Authors: Kong S-H, Lee H-J, Na J-R, Kim WG, Han D-S, Park S-H et al.

Scientific Surgery

Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery. A randomized clinical trial. JAMA Surg 2018; 153: 1081-1089.

Authors: Minnella EM, Awasthi R, Loiselle S-E, Agnihotram RV, Ferri LE, Carli F et al.

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