Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Anterior approach vs conventional hepatectomy for resection of colorectal liver metastasis. A randomized clinical trial. JAMA Surg 2021; 156: 31-40.

Authors: Rahbari NN, Birgin E, Bork U, Mehrabi A, Reißfelder C, Weitz J et al.

Scientific Surgery

Assessment of robotic versus laparoscopic distal gastrectomy for gastric cancer. A randomized controlled trial. Ann Surg 2021; 273: 858-867.

Authors: Lu J, Zheng C-H, Xu B-B, Xie J-W, Wang J-B, Lin J-X et al.

Scientific Surgery

Hypothermic machine perfusion in liver transplantation — a randomized trial. N Engl J Med 2021; 384: 1391-1401.

Authors: Van Rijn R, Schurink II, de Vries Y, van den Berg AP, Cerisuelo MC, Murad AD et al.

Scientific Surgery

Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury. A double-blind, placebo-controlled, randomized clinical trial. JAMA Surg 2020; 156: 11-20.

Authors: Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ et al.

Scientific Surgery

Prophylactic topical tranexamic acid versus placebo in surgical patients. A systematic review and meta-analysis. Ann Surg 2021; 273: 676-683.

Authors: Teoh WY, Tan TG, Ng KT, Ong KX, Chan XL, Hung T et al.

Scientific Surgery

Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vasc Surg Venous Lymphatic 2020; 8: 978-989.

Authors: Morrison N, Gibson K, Vasquez M, Weiss R, Jones A

Scientific Surgery

Prospective randomised two centre trial of endovascular repair of abdominal aortic aneurysm with or without sac embolisation. Eur J Vasc Endovasc Surg 2021; 61: 201-209.

Authors: Fabre D, Mougin J, Mitilian D, Cochennec F, Alonso CG, Becquemin J-P et al.

Scientific Surgery

Network meta-analysis of carotid endarterectomy closure Techniques. Eur J Vasc Endovasc Surg 2021; 61: 181-190.

Authors: Lazarides MK, Christaina E, Argyriou C, Georgakarakos E, Tripsianis G, Georgiadis GS et al.

Scientific Surgery

Methods of colostomy construction: no effect on parastomal hernia rate. Results from Stoma-const—a randomized controlled trial. Ann Surg 2021; 273: 640-647.

Authors: Marinez C, Bock D, Erestam S, Engström A, Kälebo P, Nielsen Y et al.

Scientific Surgery

Preventing recurrence in clean and contaminated hernias using biologic versus synthetic mesh in ventral hernia repair. The PRICE randomized clinical trial. Ann Surg 2021; 273: 648-655.

Authors: Harris H, Primus F, Young C, Carter JT, Lin M, Mukhtar R et al.

Scientific Surgery

Patient-reported outcomes of robotic vs laparoscopic ventral hernia repair with intraperitoneal mesh. The PROVE-IT randomized clinical trial. JAMA Surg 2021; 156: 22-29.

Authors: Petro CC, Zolin S, Krpata D, Alkhatib H, Tu C, Rosen MJ et al.

Scientific Surgery

Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer. The CALGB/SWOG 80702 (Alliance) randomized clinical trial. JAMA 2021; 325: 1277-1286.

Authors: Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T et al.

Scientific Surgery

Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med 2021; 384: 1191-1203.

Authors: Kelly RJ, Ajani JA, Kuzdzal J, Zander T, van Cutsem E, Piessen G et al.

Scientific Surgery

Simple wound Irrigation in the postoperative treatment for surgically drained spontaneous soft tissue abscesses: a prospective, randomized controlled trial. World J Surg 2020; 44: 4041-4051.

Authors: Oehme F, Ruhle A, Bornert K, Hempel S, Link B-C, Babst R et al.

Scientific Surgery

A multicenter randomized controlled trial comparing safety, efficacy, and cost-effectiveness of the Surgisis Anal Fistula Plug versus surgeon’s preference for trans sphincteric fistula-in-ano. The FIAT Trial. Ann Surg 2021; 273: 433-441.

Authors: Jayne D, Scholefield J, Tolan D, Gray R, Senapati A, Hulme CT et al.

Scientific Surgery

Colonic J-pouch or straight colorectal reconstruction after low anterior resection for rectal cancer: impact on quality of life and bowel function: a multicenter prospective randomized study. Dis Colon Rectum 2020; 63: 1511-1523.

Authors: Gavaruzzi T, Pace U, Giandomenico F, Pucciarelli S, Bianco F, Selvaggi F et al.

Scientific Surgery

Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum 2020; 63: 988-999.

Authors: Hajibandeh S, Hajibandeh S, Maw A

Scientific Surgery

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol Hepatol 2020; 5: 900-907.

Authors: Stevens TW, Haasnoot GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ et al.

Scientific Surgery

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. Gut 2020; 69: 1492-1501.

Authors: Kudo M, Ueshima K, Ikeda M, Torimura T, Tanebe N, Aikata H et al.

Scientific Surgery

Does negative pressure wound therapy with irrigation improve clinical outcomes? A randomized clinical trial in patients with diabetic foot infections. Am J Surg 2020 220: 1076-1082.

Authors: Lavery LA, Davis KE, La Fontaine J, Farrar JD, Bhavan K, Oz OK et al.

Scientific Surgery

Prospectively randomized controlled trial on damage control surgery for perforated diverticulitis with generalized peritonitis. World J Surg 2020; 44: 4098-4105.

Authors: Kafka-Ritsch R, Zitt M, Perathoner A, Gasser E, Kaufman C, Czipin S et al.

Scientific Surgery

Preoperative oral antibiotics and surgical-site infections in colon surgery (ORALEV): a multicentre, single-blind, pragmatic, randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 729-738.

Authors: Basany EE, Solis-Pena A, Pellino G, Kreisler E, Fraccalvieri D, Muinelo-Lorenzo M et al.

Scientific Surgery

Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis. The APPAC II randomized clinical trial. JAMA 2021; 325: 353-362.

Authors: Sipppola S, Haijanen J, Gronooos J, Rautio T, Nordstrom P, Rantanen T et al.

Scientific Surgery

Drain placement after uncomplicated hepatic resection increases severe postoperative complication rate. A Japanese multi-institutional randomized controlled trial (ND-trial). Ann Surg 2021; 273: 224-231.

Authors: Arita J, Sakamaki K, Saiura A, Konishi M, Sakamoto Y, Hashimoto M et al.

Scientific Surgery

Short-term outcomes of single-port versus multiport laparoscopic surgery for colon cancer. The SIMPLE multicenter randomized clinical trial. Ann Surg 2021; 273: 217-223.

Authors: Lee YS, Kim JH, Kim HJ, Lee SC, Kang BM, Kim CW et al.

Scientific Surgery

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open label, phase 3 trial. Lancet Oncol 2021; 22: 256-266.

Authors: Quenet F, Elias D, Roca L, Goere D, Ghouti L, Pocard M et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.

Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.

Scientific Surgery

Effect of gastric bypass vs best medical treatment on early-stage chronic kidney disease in patients with type 2 diabetes and obesity. A randomized clinical trial. JAMA Surg 2020; 155: e200420.

Authors: Cohen RV, Pereira TV, Aboud CM, Petry TBZ, Correa JLL, Schiavon CA et al.

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