Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Extending aromatase-inhibitor adjuvant therapy to 10 Years. N Engl J Med 2016; 375: 209-219.

Authors: Goss PE, Ingle JN, Pritchard KI, Robert NJ, Muss H, Gralow J et al.

Scientific Surgery

Updated results of the Gothenburg Trial of Mammographic Screening

Authors: Bjurstam NG, Björneld LM, Duffy SW

Scientific Surgery

Randomized controlled clinical trial comparing radioguided occult lesion localization with wire-guided lesion localization to evaluate their efficacy and accuracy in the localization of nonpalpable breast lesions. Surgery 2016; 159: 1140–1145.

Authors: Duarte C, Bastidas F, de los Reyes A, Martinez MC, Hurtado G, Gomez MC et al.

Scientific Surgery

Adjuvant Lapatinib and Trastuzumab for early human epidermal growth factor receptor 2–positive breast cancer: results from the randomized phase III adjuvant Lapatinib and/or Trastuzumab treatment optimization trial. J Clin Oncol 2016; 34: 1034-1042.

Authors: Piccart-Gebhart M, Holmes E, Baselga J, de Azambuja E, Dueck AC, Viale G et al.

Scientific Surgery

Mesh versus acellular dermal matrix in immediate implant-based breast reconstruction – a prospective randomized trial. Eur J Surg Oncol 2016; 42: 665–671.

Authors: Gschwantler-Kaulich D, Schrenk P, Bjelic-Radisic V, Unterrieder K, Leser C, Fink-Retter A et al.

Scientific Surgery

Are prophylactic postoperative antibiotics necessary for immediate breast reconstruction? Results of a prospective randomized clinical trial. J Am Coll Surg 2016; 222: 1116–1124.

Authors: Phillips BT, Fourman MS, Bishawi M, Zegers M, O’Hea BJ, Ganz JC et al.

Scientific Surgery

5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. Lancet 2016; 387: 229-238.

Authors: Strnad V, Ott OJ, Hildebrandt G, Kauer-Dorner D, Knauerhause H, Major T et al on behalf of the Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) et al.

Scientific Surgery

Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet 2016; 387: 341-348

Authors: Ohuchi N, Suzuki A, Sobue T, Kawai M, Yamamoto S, Zheng Y-F et al for the J-START investigator groups et al.

Scientific Surgery

Efficacy of adjuvant trastuzumab for patients With human epidermal growth factor receptor 2–positive early breast cancer and tumors ≤ 2 cm: a meta-analysis of the randomized trastuzumab trials. J Clin Oncol 2015; 33: 2600-2608.

Authors: O’Sullivan CC, Bradbury I, Campbell C, Spielmann M, Perez EA, Joensuu H et al. et al.

Scientific Surgery

Timing of adjuvant surgical oophorectomy in the menstrual cycle and disease-free and overall survival in premenopausal women with operable breast cancer. J Natl Cancer Inst 2015; 107

Authors: Love RR, Laudico AV, Van Dinh N, Allred DC, Uly GB, Quang LH et al. et al.

Scientific Surgery

Patient-reported outcomes with anastrozole versus tamoxifen for postmenopausal patients with ductal carcinoma in situ treated with lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial. Lancet 2016; 387: 857-865.

Authors: Ganz PA, Cecchni RS, Julian TB, Margolese RG, Costantino JP, Vallow LA et al. et al.

Scientific Surgery

Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial. Lancet 2016; 387: 866-873.

Authors: Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy C et al.

Scientific Surgery

Anastrozole versus tamoxifen in postmenopausal women with ductal carcinoma in situ undergoing lumpectomy plus radiotherapy (NSABP B-35): a randomised, double-blind, phase 3 clinical trial. Lancet 2016; 387: 849-856.

Authors: Margolese RG, Cecchni RS, Julian TB, Ganz PA, Costantino JP, Vallow LA et al.

Scientific Surgery

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet 2015: 386: 1351-1361.

Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

Scientific Surgery

Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet 2015; 386: 1341–1352.

Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

Scientific Surgery

SWOG S0221: A phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer. J Clin Oncol 2015; 33: 58-64.

Authors: Budd GT, Barlow WE, Moore HCF, Hobday TJ, Stewart JA, Isaacs C et al. et al.

Scientific Surgery

Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med 2015; 373: 317-327.

Authors: Poortmans PM, Collette S, Kirkove C, Van Limbergen E, Budach V, Struikmans H et al for the EORTC Radiation Oncology and Breast Cancer Groups et al.

Scientific Surgery

Regional nodal irradiation in early-stage breast cancer. N Engl J Med 2015; 373: 307-316.

Authors: Whelan TJ, Olivotto IA, Parulekar WR, Ackerman I, Chua BH, Nabid A et al for the MA.20 Study Investigators et al.

Scientific Surgery

RTOG 9804: A prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation. J Clin Oncol 2015; 33: 723-731.

Authors: McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL et al. et al.

Scientific Surgery

Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial. Lancet 2015; 385:1863–1872.

Authors: Del Mastro L, De Placido S, Bruzzi P, De Laurentis M, Boni C, Cavazzini G et al. for the Gruppo Italiano Mammella (GIM) investigators et al.

Scientific Surgery

SIS.NET: A randomized controlled trial evaluating a web-based system for symptom management after treatment of breast cancer. Cancer 2015; 121: 893–899.

Authors: Wheelock E, Bock MA, Martin EL, Hwang J, Ernest ML, Rugo HS et al. et al.

Scientific Surgery

Use of a decision aid including information on overdetection to support informed choice about breast cancer screening: a randomised controlled trial. Lancet 2015; 385: 1642-1652.

Authors: Hersch J, Barrett A, Jansen J, Irwig T, McGeechan K, Jacklyn G et al. et al.

Scientific Surgery

Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med 2015; 372: 436-446.

Authors: Francis PA, Regan MM, Fleming GF, Láng I, Ciruelos E, Bellet M et al. et al.

Scientific Surgery

Effect of radiotherapy after breast-conserving surgery for ductal carcinoma in-situ: 20 years follow-up in the randomized SweDCIS Trial. J Clin Oncol 2014; 32: 3613-3618.

Authors: Warnbery F, Garmo H, Emdin S, Hedberg V, Adwall L, Sandelin K et al. et al.

Scientific Surgery

Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med 2014; 371: 107-118.

Authors: Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Lang I et al. et al.

Scientific Surgery

Comparison of doxorubicin and cyclophosphamide versus single agent paclitaxel as adjuvant therapy for breast cancer in women with 0 to 3 positive axillary nodes: CALGB 40101 (Alliance). J Clin Oncol 2014; 32: 2311-2317.

Authors: Schulman LN, Berry DA, Cirrincione CT, Becker HP, Perez EA, O'Regan R et al. et al.

Scientific Surgery

Randomized controlled trial of yoga in women with breast cancer undergoing radiotherapy. J Clin Oncol 2014; 32: 1058-1065.

Authors: Chandwani KD, Perkins G, Nagendra HR, Raghuram NV, Spelman A, Nagarathna R et al. et al.

Scientific Surgery

Double-blind, placebo-controlled, multicentre, randomized phase IIB neoadjuvant study of letrazole-lepatinib in postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2 negative, operable breast cancer. J Clin Oncol 2014; 32: 1050-1057.

Authors: Guameri V, Generali DG, Frassoldati A, Boni C, Cavanna L, Tagliafico E et al. et al.

Scientific Surgery

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8315 women in 22 randomised trials. Lancet 2014; 383: 2127-2135.

Authors: Early Breast Cancer Trialists Collaborative Group

Scientific Surgery

Risk-adapted targeted intra-operative radiotherapy versus whole breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet 2014; 383: 603-613.

Authors: Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M et al. et al.

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