This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
A novel immune modulator for patients with necrotizing soft tissue infections (NSTI). Results of a multicenter, phase 3 randomized controlled trial of Reltecimod (AB 103). Ann Surg 2020; 272: 469-478.
Published: 15th October 2020
Authors: Bulger E, May K, Robinson BR, Evans DC, Henry S, Green J et al.
Conclusion
The composite end point of this study included: alive at day 28; three or fewer debridements; no amputation; resolution of organ dysfunction. In this study that included 290 patients the composite endpoint was not improved by intervention (intention to treat), but organ dysfunction improved in patients who received the active drug.
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