This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomised controlled trial comparing three different radiofrequency technologies: short-term results of the 3-RF Trial. Eur J Vasc Endovasc Surg 2019; 58: 401-408

Published: 23rd December 2019

Authors: Nyamekye IK, Dattani N, Hayes W, Harding D, Holloway S, Newman J et al.

Conclusion

Some 180 patients were treated with one of three radiofrequency ablation devices for their varicose veins. Closure of the great saphenous vein after six months was highest with VenefitTm (100 per cent), followed by RFITT Tm (98 per cent), and lastly EVRF Tm (79 per cent), P<0.01. Clinical outcomes and quality of life were similar.

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Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vasc Surg Venous Lymphatic 2020; 8: 978-989.

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Randomized controlled trial of compression after endovenous thermal ablation of varicose veins (COMETA Trial). Ann Surg 2021; 273: 232-239.

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Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: A randomized clinical trial. J Vasc Venous 2020; 8: 211-215.

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Role of compression after radiofrequency ablation of varicose veins: a randomised controlled trial. Eur J Vasc Endovasc Surg 2020; 60: 108-117.

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Post-procedural compression vs. no compression after radiofrequency ablation and concomitant foam sclerotherapy of varicose veins: a randomized controlled non-inferiority trial. Eur J Vasc Endovasc Surg 2020; 59: 73-80

Authors: Pihlaja T, Romsi P, Ohtonen P, Jounila J, Pokela M

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Five-year outcomes of a randomized trial of treatments for varicose veins. N Engl J Med 2019; 381: 912-922.

Authors: Brittenden J, Cooper D, Dimitrova M, Scotland G, Cotton SC, Elders A et al.

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Twenty-four month results from a randomized trial of cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vas Venous Lymphatic Disorders 2018; 6: 606–613.

Authors: Gibson K, Morrison N, Kolluri R, Vasquez M, Weiss R, Cher D et al.

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A randomized clinical trial of buffered tumescent local anaesthesia during endothermal ablation for superficial venous incompetence. Eur J Vasc Endovasc Surg 2018; 56: 699-708.

Authors: Nandhra S, Wallace T, El-Sheikha J, Leun C, Carradice D, Chetter I et al.

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Prospective, double-blind, randomized controlled trial comparing electrocoagulation and radiofrequency in the treatment of patients with great saphenous vein insufficiency and lower limb varicose veins. J Vasc Surg Venous Lymphatic 2018; 6: 212-219.

Authors: Beteli CB, Rossi FH, de Almeida BL, Izukawa NM, Rossi CBO, Gabriel SA et al.

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Systematic review and meta-analysis of randomized controlled trials evaluating long-term outcomes of endovenous management of lower extremity varicose veins. J Vasc Surg Venous Lymphat Disord 2018; 6: 256-270.

Authors: Kheirelseid EAH, Crowe G, Sehgal R, Liakopoulos D, Bela H, Mulkern E et al.

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A randomised clinical trial comparing n-butyl cyanoacrylate, radiofrequency ablation and endovenous laser ablation for the treatment of superficial venous incompetence: two year follow up results. Eur J Vasc Endovasc Surg 2018; 56: 553-560.

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VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphatic 2017; 5: 321-330.

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