This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut 2014; 63: 1617-1625.

Published: 24th February 2015

Authors: Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G et al. et al.

Conclusion

In this study that included 120 patients, five weeks of ondansetron relieved some of the most intrusive symptoms of irritable bowel syndrome: loose stools (P<0.001), frequency (P=0.002) and urgency (P<0.001), although pain scores were similar.

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