The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

Published: 24th November 2021

Authors: O’Leary DP, Walsh SM, Bolger J, Baban C, Humphreys H, O’Grady S et al.


In this trial that included 186 randomized patients, 25.3 per cent of the antibiotic group had recurrent appendicitis within one year. Quality of life after three months and one year were better in the surgery group (both P<0.001). Total costs were higher in the surgery group.

Pubmed Link