This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized controlled clinical trial. No clear benefit to prophylactic central neck dissection in patients with clinically node negative papillary thyroid cancer. Ann Surg 2020; 272: 496-503.

Published: 20th October 2020

Authors: Sippel RS, Robbins SE, Poehls JL, Pitt SC, Chen H, Leverson G et al.

Conclusion

Sixty patients were included. One third who had central node dissection had microscopic nodal involvement. Oncological outcomes were similar after one year.

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Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double blind, phase 3 trial. Lancet 2014; 384: 319-328.

Authors: Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L et al. et al.

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Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized double-blind phase III trial. J Clin Oncol 2012; 30: 134-141.

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Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid. Ann Surg 2001; 233: 716-22.

Authors: Udelsman R, Westra WH, Donovan PI, Sohn TA, Cameron JL.