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A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med 2020; 383: 1907-1919.

Published: 19th March 2021

Authors: The CODA Collaborative


Of 1552 patients with appendicitis, 776 were randomized to receive antibiotics (47% treated as an outpatient). At 30 days, antibiotic treatment was non-inferior to surgery based on EQ-5D scores. In those who had antibiotics, 29 per cent had undergone appendicectomy within 90 days: 41 per cent of those with an appendicolith and 29 per cent without. Serious adverse event rates were similar.

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