This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med 2012; 366: 1414–1422.

Published: 27th August 2012

Authors: Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosier P, Higgins PDR et al. et al.

Conclusion

Postoperative pancreatitis (three-fold rise in amylase, new abdominal pain) developed in 9.2 per cent of patients who had indomethacin versus 16.9 per cent of controls in this study that included 602 high risk patients (P=0.005). Pancreatitis was moderate to severe in 4.4 and 8.8 per cent, respectively (P=0.03).

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