This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 2015; 373: 1519-1530.

Published: 5th January 2016

Authors: Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC et al. et al.

Conclusion

A total of 2259 patients with no polyps left after colonoscopic polypectomy were included. Overall, 43 per cent of patients developed recurrent polyps over three to five years. Risk ratios were 0.99, 95 per cent confidence interval 0.89 to 1.09 for vitamin D supplements alone; 0.95, 0.89 to 1.06 for calcium; and 0.93, 0.8 to 1.08 for both.

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A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

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Long-term outcomes of a randomized controlled trial of single-incision versus multi-port laparoscopic colectomy for colon cancer. Ann Surg 2021; 273: 1060-1065.

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Authors: Balvardi S, Pecorelli N, Castelino T, Niculiseanu P, Alhashemi M, Liberman AS et al.