The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Abelacimab for prevention of venous thromboembolism. N Engl J Med 2021; 385: 609-617.

Published: 9th December 2021

Authors: Verhamme P, Yi BA, Segers A, Salter J, Bloomfield D, Buller HR et al.


A single dose of this factor XI inhibitor in patients undergoing knee surgery reduced the rate of postoperative venous thromboembolism (P<0.001) compared to standard Enoxaparin thromboprophylaxis, without increasing the risk of bleeding.

Pubmed Link