This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Adjuvant chemoradiotherapy with epirubicin, cisplatin, and fluorouracil compared with adjuvant chemoradiotherapy with fluorouracil and leucovorin after curative resection of gastric cancer: results from CALGB 80101 (Alliance). J Clin Oncol 2017; 35: 3671-3677.

Published: 17th May 2018

Authors: Fuchs CS, Niedzwiecki D, Mamon HJ, Tepper JE, Xing Y, Swanson RS et al.

Conclusion

Some 546 patients were included and followed for a median 6.5 years. The new regimen did not improve overall 5-year survival (44 per cent in both groups) or disease-free survival: 37 per cent, versus 39 per cent with standard chemotherapy.

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Phase III trial to compare adjuvant chemotherapy with capecitabine and cisplatin versus concurrent chemoradiotherapy in gastric cancer: final report of the adjuvant chemoradiotherapy in stomach tumors trial, including survival and subset analyses. J Clin Oncol 2015; 33: 3130-3136.

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