This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. N Engl J Med 2018; 379:111-121.
Published: 17th September 2018
Authors: Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF et al.
Conclusion
This trial included over then thousand women with ER positive, HER-2 negative breast cancer. Endocrine therapy alone was not inferior: hazard ratio for disease recurrence, second primary or death 1.09, 95 per cent confidence interval 0.94 to 1.24. Chemotherapy may benefit women aged 50 and under.
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