This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma. N Engl J Med 2017; 377: 1813-1823.

Published: 25th January 2018

Authors: Long GV, Hauschild A, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V et al.

Conclusion

In this trial that included 870 patients, compared with placebo, active oral combination treatment improved 3-year relapse-free survival from 39 to 58 per cent, P<0.001, and overall survival from 77 to 86 per cent, P=0.0006.

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