This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant letrozole and tamoxifen alone or sequentially for postmenopausal women with hormone receptor–positive breast cancer: long-term follow-up of the BIG 1-98 Trial. J Clin Oncol 2019; 37: 105-114.
Published: 12th November 2019
Authors: Ruhstaller T, Giobbie-Hurder A, Colleoni M, Jensen M-B, Ejlertson B, de Azambuja E et al.
Conclusion
This four way trial examined outcomes at a median of 12.6 years of follow-up; 3833 women remained in the study. For monotherapy, letrozole improved disease-free survival (hazard ratio 0.91, 95 per cent confidence interval 0.8 to 1.01). Letrozole reduced contralateral cancers for the first ten years, after which this reversed.
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