This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant pertuzumab and trastuzumab in early HER2-positive breast cancer. N Engl J Med 2017; 377: 122-131.
Published: 30th September 2017
Authors: von Minckwitz G, Procter M, de Azambuja E, Zardavas D, Benyunes M, Viale G et al.
Conclusion
This study included 4805 women. The addition of pertuzumab reduced disease recurrence (hazard ratio 0.81, 95 per cent confidence interval 0.66 to 1.0, P=0.045). The effect was greater in women with node positive disease (0.77, 0.62 to 0.96, P=0.02).
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