This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial. J Natl Cancer Inst 2007; 99: 601-607.
Published: 1st January 2007
Authors: Cascinu S, Labianca R, Barone C, Santoro A, Carnaghi C, Cassano A et al.
Conclusion
Some 400 patients were included and randomized to two different adjuvant chemotherapy regimens. There was no benefit from intensive chemotherapy (which was completed in only 9.4 per cent of patients): overall 5-year survival was 52 vs. 50 per cent, relative risk 0.95, 95 per cent confidence interval 0.7 to 1.29.
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