This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 2020; 382: 1599-1607

Published: 15th June 2020

Authors: Agnelli G, Becattini C, Meyer G, Munoz A, Huisman MV, Connors JM et al.

Conclusion

Some 1155 patients with a DVT and cancer were randomly assigned apixaban or dalteparin low molecular weight heparin injections for six months. Respective rates of recurrent venous thromboembolism were similar: 5.6 versus 7.9 per cent, P<0.001 for non-inferiority. Bleeding complication rates were also similar.

Pubmed Link

You may also be interested in

Scientific Surgery

Abelacimab for prevention of venous thromboembolism. N Engl J Med 2021; 385: 609-617.

Authors: Verhamme P, Yi BA, Segers A, Salter J, Bloomfield D, Buller HR et al.

Scientific Surgery

Intermittent pneumatic compression in addition to standard prophylaxis of postoperative venous thromboembolism in extremely high-risk patients (IPC SUPER): a randomized controlled trial. Ann Surg 2021; 274: 63-69.

Authors: Lobastov K, Sautina E, Alencheva E, Bargandzhiya A, Schastlivtsev I, Barinov V et al.

Scientific Surgery

Adjunctive intermittent pneumatic compression for venous thromboprophylaxis. N Engl J Med 2019; 380: 1305-1315.

Authors: Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS et al.

Scientific Surgery

Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: Systematic review and meta-analysis of randomized clinical trials. Surgery 2018; 164: 1234-1240.

Authors: Rausa E, Kelly ME, Asti E, Aiolfi A, Bonitta G, Winter DC et al.

Scientific Surgery

Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer. N Engl J Med 2019; 380: 720-728.

Authors: Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T et al.

Scientific Surgery

Apixaban to prevent venous thromboembolism in patients with cancer. N Engl J Med 2019; 380: 711-719.

Authors: Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, Shivakumar S, Schattner A et al.

Scientific Surgery

Thromboembolism incidence and prophylaxis use after gastrectomy among Korean patients with gastric adenocarcinoma. The PROTECTOR randomized clinical trial. JAMA Surg 2018; 153: 939-946.

Authors: Jung YJ, Seo HS, Park CH, Jeon HM, Kim J-I, Yim HW et al.

Scientific Surgery

Venous thromboembolism incidence and prophylaxis use after gastrectomy among Korean patients with gastric adenocarcinoma. The PROTECTOR randomized clinical trial. JAMA Surg 2018; 153: 939-946.

Authors: Jung YJ, Seo HS, Park CY, Jeon HM, Kim J-I, Yim HW et al.

Scientific Surgery

Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial. Lancet Haematol 2018; 1: e25-e33.

Authors: Ten Cate-Hoek AJ, Amin EE, Bouman AC, Meijer K, Tick LW, Middeldorp S et al.

Scientific Surgery

Randomized double-blinded study comparing medical treatment versus iliac vein stenting in chronic venous disease. J Vasc Surg Venous Lymphatic 2018; 6: 183-191.

Authors: Rossi FH, Kambara AM, Izukawa NM, Rodrugues TO, Rossi CB, Sousa AG et al.

Scientific Surgery

Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 2018; 378: 615-624.

Authors: Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D et al.

Scientific Surgery

Pharmacomechanical catheter-directed thrombolysis for deep-vein thrombosis. N Engl J Med 2017; 377: 2240-2252.

Authors: Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ et al.