This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Are postoperative intravenous antibiotics indicated after laparoscopic appendicectomy for simple appendicitis? A prospective double-blinded randomized controlled trial. Ann Surg 2020; 272: 248-252.

Published: 16th September 2020

Authors: Mennie N, Panabokke G, Chang A, Tanny ST, Cheng W, Pacilli M et al.

Conclusion

Some 243 children were randomized to two doses of antibiotics postoperatively, or placebo. There were eight wound infections in the placebo group, and only one after antibiotic prophylaxis (P=0.01).

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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