This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the Investigating Gram-Negative Infections Treated with Eravacycline (IGNITE 1) trial. A randomized clinical trial. JAMA Surg 2017; 152: 224-232.

Published: 14th June 2017

Authors: Solomkin J, Evans D , Slepavicius A, Lee P, Marsh A, Tsai L et al.

Conclusion

Both treatments were effective in this study that included 541 patients: clinical cure rates were 86.8 per cent with eravacycline and 87.6 per cent with ertapenem.

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Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021; 397: 2253-2263.

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Biomarker-guided intervention to prevent acute kidney injury after major surgery: the prospective randomized BigpAK Study. Ann Surg 2018; 267: 1013-1020.

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Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 2018; 378: 2263-2274.

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Low versus standard urine output targets in patients undergoing major abdominal surgery: a randomized noninferiority trial. Ann Surg 2017; 265: 874-881.

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Authors: Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RML, Santhakumaran S et al.

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Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016; 388: 1377–1388.

Authors: Schaller SJ, Anstey M, Blobner M, Edrich T, Grabitz SD, Gradwohl-Matis I et al.

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Intraoperative goal-directed fluid therapy in elective major abdominal surgery: a meta-analysis of randomized controlled trials. Ann Surg 2016; 263: 465-476.

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