This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Bevacizumab in stage II-III colon cancer: five year update of the National Surgical Adjuvant Breast and Bowel Project C-08 Trial. J Surg Oncol 2013; 31: 359-364.
Published: 12th December 2013
Authors: Allegra CJ, Yothers G, O’Connell MJ, Sharif S, Petrelli NJ, Lopa SH et al. et al.
Conclusion
In this study that included 2673 patients, the addition of bevacizumab to FOLFOX6 for twelve months did not improve disease-free (hazard ratio 0.93, 95 per cent confidence interval 0.81 to 1.08, P=0.35) or overall survival (0.95, 0.79 to 1.13, P=0.99) after median follow-up of five years.
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