This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.
Published: 25th August 2020
Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.
Conclusion
Some 861 people were randomised between 1999 and 2005, and followed for a mean of ten years. Aspirin significantly reduced the risk of colorectal cancer: hazard ratio 0.65, 95 per cent confidence interval 0.43 to 0.97, P=0.35. Adverse event rates were similar.
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