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Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.

Published: 25th August 2020

Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.


Some 861 people were randomised between 1999 and 2005, and followed for a mean of ten years. Aspirin significantly reduced the risk of colorectal cancer: hazard ratio 0.65, 95 per cent confidence interval 0.43 to 0.97, P=0.35. Adverse event rates were similar.

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