This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Celecoxib for the prevention of colorectal adenomas: results of a suspended randomized controlled trial. J Natl Cancer Inst 2016; 108: djw151.

Published: 26th April 2017

Authors: Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F et al.

Conclusion

The trial was stopped when celecoxib was withdrawn, but patients continued to be randomized to selenium versus placebo. In patients who had colonoscopy within a year of stopping celecoxib, recurrence of adenomas was reduced: relative risk 0.69, 95 per cent confidence interval 0.48 to 0.98, P=0.04.

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