This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Central venous access devices for the delivery of systemic anticancer therapy (CAVA): a randomised controlled trial. Lancet 2021; 398: 403-415.

Published: 9th December 2021

Authors: Moss JG, Wo O, Bodenham AR, Agarwal R, Menne TF, Jones BL et al.

Conclusion

Three implantable devices for intravenous therapy were compared in this study that included 1061 patients. Totally implanted ports were shown to be safer than Hickman and PICC lines, with fewer complications.

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Scientific Surgery

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021; 397: 2253-2263.

Authors: Lopes RD, de barros e Silva PGM, Furtado RHM, Macedo AVS, Bronhara B, Damiani LP et al.

Scientific Surgery

Primary open versus closed implantation strategy for totally implantable venous access ports. The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900). Ann Surg 2020; 272: 950-960.

Authors: Hüttner F, Bruckner T, Hackbusch M, Weitz J, Bork U, Kotschenreuther P et al.

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Effect of hydroxyethyl starch vs saline for volume replacement therapy on death or postoperative complications among high-risk patients undergoing major abdominal surgery. The FLASH randomized clinical trial. JAMA 2020; 323: 225-236

Authors: Futier E, Garot M, Godet T, Biais M, Verzilli D, Ouattara A et al.

Scientific Surgery

Biomarker-guided intervention to prevent acute kidney injury after major surgery: the prospective randomized BigpAK Study. Ann Surg 2018; 267: 1013-1020.

Authors: Göcze I, Jauch D, Götz M, Kennedy P, Jung B, Zeman F et al.

Scientific Surgery

Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 2018; 378: 2263-2274.

Authors: Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D et al.

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Low versus standard urine output targets in patients undergoing major abdominal surgery: a randomized noninferiority trial. Ann Surg 2017; 265: 874-881.

Authors: Puckett J, Pickering JW, Palmer S, McCall JL, Kluger MT, De Zoysa J et al.

Scientific Surgery

Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the Investigating Gram-Negative Infections Treated with Eravacycline (IGNITE 1) trial. A randomized clinical trial. JAMA Surg 2017; 152: 224-232.

Authors: Solomkin J, Evans D , Slepavicius A, Lee P, Marsh A, Tsai L et al.

Scientific Surgery

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet 2016; 388: 1893–1902.

Authors: Su X, Meng Z-T, Wu X-H, Cui F, Li H-L, Wang D-X et al.

Scientific Surgery

Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 2016; 375: 1638-1648.

Authors: Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RML, Santhakumaran S et al.

Scientific Surgery

Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016; 388: 1377–1388.

Authors: Schaller SJ, Anstey M, Blobner M, Edrich T, Grabitz SD, Gradwohl-Matis I et al.

Scientific Surgery

Intraoperative goal-directed fluid therapy in elective major abdominal surgery: a meta-analysis of randomized controlled trials. Ann Surg 2016; 263: 465-476.

Authors: Rollins K, Lobo D

Scientific Surgery

Efficacy and safety of glutamine-supplemented parenteral nutrition in surgical ICU patients: an American multicenter randomized controlled trial. Ann Surg 2016; 263: 646-655.

Authors: Ziegler T, May A, Hebbar G, Easley KA, Griffith DP, Dave N et al.