The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med 2018; 379: 215-225.

Published: 17th September 2018

Authors: Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ et al.

Conclusion

Some 4881 patients were randomized. The combination therapy reduced major ischaemic events (5 versus 6.5 per cent, P=0.02), but increased the risk of major haemorrhage (0.9 versus 0.4 per cent, P=0.02).

Pubmed Link