The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Clopidogrel with aspirin in acute minor stroke or transient ischemic attack (CHANCE) trial. Circulation. 2015; 132: 2-3.

Published: 29th October 2015

Authors: Wang Y, Pan Y, Zhao X, Li H, Wang D, Claiborne Johnston S et al. on behalf of the CHANCE Investigators et al.

Conclusion

The addition of clopidogrel to aspirin for 90 days after TIA or minor stroke reduced the stroke rate at 1 year from 14 to 10.6 per cent (hazard ratio 0.78, 95 per cent confidence interval 0.65 to 0.93, P=0.006) in this multicentre study that included 5170 patients.

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