This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis. BMJ Open 2019; 9: e032773

Published: 23rd December 2019

Authors: Jodal HC, Helsingen LM, Anderson JC, Lytvyn L, Vandvik PO, Emilsson L et al.

Conclusion

This updated meta-analysis included twelve RCTs. Compared with no screening, sigmoidoscopy screening reduced colorectal cancer incidence (relative risk 0.76, 95 per cent confidence interval 0.7 to 0.83) and mortality (0.74, 0.69 to 0.8). Faecal occult blood testing had no effect on colorectal cancer incidence, but reduced colorectal cancer mortality (0.69, 0.56 to 0.86).

Pubmed Link

You may also be interested in

Scientific Surgery

Effect of a single aspirin dose prior to fecal immunochemical testing on test sensitivity for detecting advanced colorectal neoplasms. A randomized clinical trial. JAMA 2019; 321: 1686-1692.

Authors: Brenner H, Calderazzo S, Seufferlein T, Ludwig L, Dikopoulos N, Mangold J et al.

Scientific Surgery

Effect of colonoscopy outreach vs fecal immunochemical test outreach on colorectal cancer screening completion. A randomized clinical trial. JAMA 2017; 318: 806-815.

Authors: Singal AG, Gupta S, Skinner CS, Ahn C, Santini NO, Agrawal D et al.

Scientific Surgery

Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet 2017; 389: 1299–1311.

Authors: Atkin W , Wooldrage K, Parkin DM, Kralj-Hans I, MacRae E, Shah U et al.

Scientific Surgery

Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials. BMJ 2017; 356: i6673.

Authors: Holme Ø , Schoen RE, Senore C, Segnan N, Hoff G, Løberg M et al.

Scientific Surgery

Randomized comparison of surveillance intervals in familial colorectal cancer. J Clin Oncol 2015; 33: 4188-4193.

Authors: Hennink SD, van Der Meulen-de Jong AE, Wolterbeek R, Crobach ASLP, Becx MCJM, Crobach WSFJ et al. et al.

Scientific Surgery

Effects of evidence-based strategies to reduce the socioeconomic gradient of uptake in the English NHS Bowel Cancer Screening Programme (ASCEND): four cluster-randomised controlled trials. Lancet 2016; 387: 751-759.

Authors: Wardle J, von Wagner C, Kralj-Hans I, Halloran SP, Smith SG, McGregor LM et al. et al.

Scientific Surgery

Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ 2014; 348: g2467.

Authors: Brenner H, Stock C, Hoffmeister M

Scientific Surgery

Long-term mortality after screening for colorectal cancer. N Engl J Med 2013; 369: 1106-1141.

Authors: Shaukat A, Mongin SJ, Geisser MS, Lederle FA, Bond JH, Mandel JS et al. et al.

Scientific Surgery

Effect of flexible sigmoidoscopy-based screening on incidence and mortality of colorectal cancer: a systematic review and meta-analysis of randomised controlled trials. Plos MED 2012; 9: e1001352.

Authors: Elmunzer BJ, Hayward RA, Schoenfeld PS, Saini SD, Deshpande A, Waljee AK et al.

Scientific Surgery

Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med 2012; 366: 2345–2357.

Authors: Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO et al. et al.

Scientific Surgery

Nottingham trial of faecal occult blood testing for colorectal cancer: a 20-year follow-up. Gut 2012; 61: 1036–1040.

Authors: Scholefield JH, Moss SM, Mangham CM, Whynes DK, Hardcastle JD

Scientific Surgery

Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian randomized controlled trial – SCORE. J Natl Cancer Inst 2011; 103: 1310–1322.

Authors: Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M et al. et al.