This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

The cost of postoperative pancreatic fistula versus the cost of pasireotide: results from a prospective randomized trial. Ann Surg 2017; 265: 11-16.

Published: 1st March 2017

Authors: Ma LW , Dominguez-Rosado I, Gennarelli RL, Bach PB, Gonen M, D’Angelica M et al.

Conclusion

This study included 300 procedures. Pasireotide significantly reduced the rate of significant postoperative pancreatic fistula (9 versus 21 percent, P=0.006), but taking into account the cost of the medication, there was no significant reduction in mean overall hospital costs.

Pubmed Link

You may also be interested in

Scientific Surgery

Safety of combined division vs separate division of the splenic vein in patients undergoing distal pancreatectomy. A noninferiority randomized clinical trial. JAMA Surg 2021; 156: 418-428.

Authors: Yamada S, Fujii T, Sonohara F, Kawai M, Shibuya K, Matsumoto I et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

A systematic review and network-meta-analysis of gastro-enteric reconstruction techniques following pancreatoduodenectomy to reduce delayed gastric emptying. World J Surg 2020; 44: 2314-2322.

Authors: Kamarajah SK, Bundred JR, Alessandri G, Robinson SM, Wilson CH, French JJ et al.

Scientific Surgery

Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis. A single-center, phase 3, randomized clinical trial. JAMA Surg 2020; 155: 313-321.

Authors: Andrianello S, Marchegiani G, Malleo G, Masini G, Balduzzi A, Paiella S et al.

Scientific Surgery

Effect of hydrocortisone vs pasireotide on pancreatic surgery complications in patients with high risk of pancreatic fistula. A randomized clinical trial. JAMA Surg 2020; 155: 291-298.

Authors: Tarvainen T, Siren J, Kokkola A, Sallinen V

Scientific Surgery

Results of a randomized controlled trial comparing closed-suction drains versus passive gravity drains after pancreatic resection. Surgery 2018; 164: 1057-1063.

Authors: Čečka F, Jon B, Skalický P, Čermáková E, Neoral C, Loveček M et al.

Scientific Surgery

Modified Blumgart mattress suture versus conventional interrupted suture in pancreaticojejunostomy during pancreaticoduodenectomy. Randomized controlled trial. Ann Surg 2019; 269: 243–251.

Authors: Hirono S, Kawai M, Okada K-I, Miyazawa M, Kitahata Y, Hayami S et al.

Scientific Surgery

Minimally invasive versus open distal pancreatectomy (LEOPARD). A multicenter patient-blinded randomized controlled trial. Ann Surg 2019; 269: 2-9.

Authors: de Rooij T, van Hilst J, van Santvoort H, Boerma D, van den Boezem P, Daams F et al.

Scientific Surgery

Comparison of perioperative outcomes between laparoscopic and open approach for pancreatoduodenectomy: the PADULAP randomized controlled trial. Ann Surg 2018; 268: 731-739.

Authors: Poves I, Burdío F, Morató O, Iglesias M, Radosevic A, Ilzarbe L et al.

Scientific Surgery

Pylorus resection does not reduce delayed gastric emptying after partial pancreatoduodenectomy: a blinded randomized controlled trial (PROPP Study, DRKS00004191). Ann Surg 2018; 267: 1021-1027.

Authors: Hackert T, Probst P, Knebel P, Doerr-Harim C, Bruckner T, Klaiber U et al.