This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. Lancet 2018; 391: 2325-2334.

Published: 22nd November 2018

Authors: Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM et al.

Conclusion

Some 1754 patients with raised troponin levels postoperatively, indicating myocardial injury, were included. Major adverse vascular events occurred in 11 per cent on dabigatran and 15 per cent on placebo; hazard ratio 0.72, 95 per cent confidence interval 0.55 to 0.93, P=0.0115.

Pubmed Link

You may also be interested in

Scientific Surgery

Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

Authors: Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger TS, Kranke P et al.

Scientific Surgery

Prophylactic topical tranexamic acid versus placebo in surgical patients. A systematic review and meta-analysis. Ann Surg 2021; 273: 676-683.

Authors: Teoh WY, Tan TG, Ng KT, Ong KX, Chan XL, Hung T et al.

Scientific Surgery

Meta-analysis, meta-regression, and GRADE assessment of randomized and nonrandomized studies of incisional negative pressure wound therapy versus control dressings for the prevention of postoperative wound complications. Ann Surg 2020; 272: 81-91.

Authors: Zwanenburg P, Tol BT, Obdeijn MC, Lapid O, Gans SL, Boermeester MA et al.

Scientific Surgery

Incisional surgical site infection after abdominal fascial closure with Triclosan-coated barbed suture vs Triclosan-coated polydioxanone loop suture vs polydioxanone loop suture in emergent abdominal surgery. A randomized clinical trial. J Am Coll Surg 2020; 230: 766-774.

Authors: Ruiz-Tovar J, Llavero C, Jimenez-Fuertes M, Duran M, Perez-Lopez M, Garcia-Marin A et al.

Scientific Surgery

Effect of cricoid pressure compared with a sham procedure in the rapid sequence induction of anesthesia. The IRIS Randomized Clinical Trial. JAMA Surg 2019; 154: 9-17

Authors: Birenbaum A, Hajage D, Roche S, Ntouba A, Eurin M, Cuvillon P et al.

Scientific Surgery

Effect of intraoperative high positive end-expiratory pressure (PEEP) with recruitment maneuvers vs low PEEP on postoperative pulmonary complications in obese patients. A randomized clinical trial. JAMA 2019; 321: 2305-2292

Authors: Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology

Scientific Surgery

Prophylactic negative pressure wound therapy in closed abdominal incisions: a meta-analysis of randomised controlled trials. World J Surg 2019; 43: 2779–2788

Authors: Wells CI, Ratnayake CBB, Perrin J, Pandanaboyana S

Scientific Surgery

Perioperative fluid restriction in abdominal surgery: a systematic review and meta-analysis. World J Surg 2019; 43: 2747-2755

Authors: Yanfei S, Guolong C, Shijin G, Jing Y

Scientific Surgery

The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer. A systematic review and meta-analysis. Ann Surg 2019; 270: 247-256

Authors: Adiamah A , Skořepa P, Weimann A , Lobo D

Scientific Surgery

Negative pressure wound therapy for surgical-site infections. A randomized trial. Ann Surg 2019; 269: 1034-1040.

Authors: Javed A, Teinor J, Wright M, Ding D, Burkhart RA, Hundt J et al.

Scientific Surgery

Effect of triclosan-coated sutures on the incidence of surgical site infection after abdominal wall closure in gastroenterological surgery: a double-blind, randomized controlled trial in a single center. Surgery 2018; 164: 91-95.

Authors: Ichida K, Noda H, Kikugawa R, Hasegawa F, Obitsu T, Ishioka D et al.

Scientific Surgery

Open vs closed negative pressure wound therapy for contaminated and dirty surgical wounds: a prospective randomized comparison. J Am Coll Surg 2018; 226: 507-512.

Authors: Frazee R, Manning A, Abernathy S, Isbell C, Isbell T, Kurek S et al.