The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. Lancet 2018; 391: 2325-2334.

Published: 22nd November 2018

Authors: Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM et al.

Conclusion

Some 1754 patients with raised troponin levels postoperatively, indicating myocardial injury, were included. Major adverse vascular events occurred in 11 per cent on dabigatran and 15 per cent on placebo; hazard ratio 0.72, 95 per cent confidence interval 0.55 to 0.93, P=0.0115.

Pubmed Link