This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
De-escalation strategies in human epidermal growth factor receptor 2 (HER2)–positive early breast cancer (BC): final analysis of the West German Study Group Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial optimizing risk assessment and therapy response prediction in early BC HER2- and hormone receptor–positive phase II randomized trial—efficacy, safety, and predictive markers for 12 weeks of neoadjuvant trastuzumab emtansine with or without endocrine therapy (ET) versus trastuzumab plus ET. J Clin Oncol 2017; 35: 3046-3054.
Published: 5th January 2018
Authors: Harbeck N, Gluz O, Christgen M, Kates RE, Braun M, Küemmel S et al.
Conclusion
This study included 375 women with a particular subtype of breast cancer that is known to be less sensitive to chemotherapy. The combination of trastuzumab with endocrine therapy improved response from 15 to 41 per cent, P<0.001.
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