This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Does a longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer? Three years’ follow-up results of the Greccar-6 randomized multicenter trial. Ann Surg 2019; 270: 747-754

Published: 23rd December 2019

Authors: Lefèvre J, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C et al.

Conclusion

This study compared 7 and 11-week waits between neoadjuvant therapy and surgery in 265 patients. There was no adverse effect of waiting for 11 weeks, as three year overall (89 per cent) and disease-free survival rates (68.7 per cent) were similar.

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Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicenter, open-label, randomized trial. Lancet Gastroenterol Hepatol 2019; 4: 761-770

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A randomized control trial of preoperative oral antibiotics as adjunct therapy to systemic antibiotics for preventing surgical site infection in clean contaminated, contaminated, and dirty type of colorectal surgeries. Dis Colon Rectum 2017; 60: 1291-1298.

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