The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med 2018; 378: 1177-1188.

Published: 17th May 2018

Authors: Grothey A, Sobrero AF, Shields AF, Yoshino T, Paul J, Taieb J et al.

Conclusion

This pooled analysis of six RCTs included 12,834 patients. The two regimens had similar effects. Three months of the capecitabine-based regimen was as effective as six months.

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A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

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Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

Authors: Zhu D, Xia J, Gu Y, Lin J, Ding K, Zhou B et al.

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Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer. The CALGB/SWOG 80702 (Alliance) randomized clinical trial. JAMA 2021; 325: 1277-1286.

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Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open label, phase 3 trial. Lancet Oncol 2021; 22: 256-266.

Authors: Quenet F, Elias D, Roca L, Goere D, Ghouti L, Pocard M et al.

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Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 2020; 21: 1620-1629.

Authors: Andre T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I et al.

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Perioperative FOLFOX 4 versus FOLFOX 4 plus Cetuximab versus immediate surgery for high-risk stage II and III colon cancers. A phase II multicenter randomized controlled trial (PRODIGE 22). Ann Surg 2020; 271: 637-645

Authors: Karoui M, Rullier A, Piessen G, Legoux JL, Barbier E, De Chaisemartin C et al.

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Quality of life after curative resection for rectal cancer in patients treated with adjuvant chemotherapy compared with observation: results of the randomized phase III SCRIPT Trial. Dis Colon Rectum 2019; 62: 711-720

Authors: van der Valk MJ, Hilling DE, Meershoek-Klein Kranenbarg E, Peeters K, Kapiteijn E, Tsonaka R et al.

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Does a longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer? Three years’ follow-up results of the Greccar-6 randomized multicenter trial. Ann Surg 2019; 270: 747-754

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Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicenter, open-label, randomized trial. Lancet Gastroenterol Hepatol 2019; 4: 761-770

Authors: Klaver CEL, Wisselink DD , Punt CJA , Snaebjornsson P , Crezee J, Aalbers AG et al.

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Authors: Dewinter G, Coppens S, Van de Velde M, D’Hoore A, Wolthuis A, Cuypers E et al.

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A randomized control trial of preoperative oral antibiotics as adjunct therapy to systemic antibiotics for preventing surgical site infection in clean contaminated, contaminated, and dirty type of colorectal surgeries. Dis Colon Rectum 2017; 60: 1291-1298.

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Authors: Dulskas A, Klimovskij M, Vitkauskiene M, Samalavicius N