This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Duration of adjuvant aromatase-inhibitor therapy in postmenopausal breast cancer. N Engl J Med 2021; 385: 395-405.
Published: 24th November 2021
Authors: Gnant M, Fitzal F, Rinnerthaler G, Steger GS, Greil-Ressler S, Balic M et al.
Conclusion
After five years of therapy, 3484 women were randomly allocated to two or five further years of Anastrozole treatment. After eight years, there was no difference in survival between the groups (hazard ratio 0.99, 95 per cent confidence interval 0.85 to 1.15, P=0.9), but women who had the longer course were more likely to have a bone fracture.
Pubmed LinkYou may also be interested in
Scientific Surgery
Authors: Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P et al.
Scientific Surgery
Authors: Wang X, Wang S-S, Huang H, Cai L, Peng R-J, Lin Y et al.
Scientific Surgery
Authors: Mittendorf EA, Zhang H, Barrios CH, Saji S, Jung KH, Hegg R et al.
Scientific Surgery
Authors: Papakonstantinou A, Matikas A, Bengtsson NO, Malmstrom P, Hedayati E, Steger G et al.
Scientific Surgery
Authors: Gralow JR, Barlow WE, Paterson AHG, M’iao JL, Lew DL, Stopeck AT et al.
Scientific Surgery
Authors: Brunt AM, Haviland JS, Wheatley DA, Sydenham MA, Alhasso A, Bloomfield DJ et al.
Scientific Surgery
Authors: Su Y, Huang J, Wang S, Unger JM, Arias-Fuenzalida J, Shi Y et al.
Scientific Surgery
Authors: Yu K-D, Wu S-Y, Liu G-Y, Wu J, Di G-H, Hu Z et al.
Scientific Surgery
Authors: Nitz M, Gluz O, Clemens M, Malter W, Reimer T, Nuding B et al.
Scientific Surgery
Authors: Schmid P, Cortes J, Pusztai L, McArthur H, Kummel S, Bergh J et al.
Scientific Surgery
Authors: Whelan TJ, Julian JA, Berrang TS, Kim D-H, Germain I, Nichol AM et al.
Scientific Surgery
Authors: Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA et al.