The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Duration of adjuvant aromatase-inhibitor therapy in postmenopausal breast cancer. N Engl J Med 2021; 385: 395-405.

Published: 24th November 2021

Authors: Gnant M, Fitzal F, Rinnerthaler G, Steger GS, Greil-Ressler S, Balic M et al.


After five years of therapy, 3484 women were randomly allocated to two or five further years of Anastrozole treatment. After eight years, there was no difference in survival between the groups (hazard ratio 0.99, 95 per cent confidence interval 0.85 to 1.15, P=0.9), but women who had the longer course were more likely to have a bone fracture.

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