This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 2018; 378: 615-624.

Published: 17th May 2018

Authors: Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D et al.

Conclusion

Some 1046 patients were randomized to oral Edoxaban or low molecular weight heparin (Dalteparin) for at least six months. At twelve months, recurrent venous thromboembolism was lower with Edoxaban (7.9 versus 11.3 per cent), but major bleeding rates were higher (6.9 versus 4 per cent); all non-significant.

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Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 2020; 382: 1599-1607

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